Evidence map›Paper›PMID 31938365›Full record

ArticleInternational journal of clinical and experimental pathology2018

miR-455-3p functions as a tumor suppressor in colorectal cancer and inhibits cell proliferation by targeting TPT1.

Yuanyuan Sun, Yan Wang, Hainan Yang, Yan Xu, Haipeng Yu

Open access · greenAbstract read
In one paragraph

Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Yuanyuan SunDepartment of Medical Oncology, Capital Medical University Cancer Center, Beijing Shijitan Hospital, Beijing Key Lab of Therapeutic Cancer Vaccines Beijing, P. R. China.
Yan WangDepartment of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy for Tianjin Tianjin, P. R. China.
Hainan YangDepartment of Medical Oncology, The Ninth Teaching Hospital of Peking University Health Science Center, Beijing Shijitan Hospital, Beijing Key Lab of Therapeutic Cancer Vaccines Beijing, P. R. China.
Yan XuDepartment of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy for Tianjin Tianjin, P. R. China.
Haipeng YuDepartment of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy for Tianjin Tianjin, P. R. China.
Tianjin Medical University Cancer Institute and Hospital · CNBeijing Shijitan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing studies have revealed the importance of microRNAs (miRNAs) in tumorigenesis and tumor progression. miR-455-3p is a newly identified tumor suppressive RNA in various human cancers. However, the expression pattern and clinical significance of miR-455-3p in colorectal cancer (CRC) remains unclear. We found that expression of miR-455-3p was significantly reduced in CRC tissues and cell lines. In addition, we show that low miR-455-3p expression is associated with larger tumor size, advanced tumor stage, and poorer overall survival of CRC patients. Furthermore,

Indexed as

cell cyclecolorectal cancermiR-455-3pproliferationTPT1

Identifiers

PMID31938365
PMCPMC6958251
OpenAlexW3013293159

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.