ArticleInternational journal of clinical and experimental pathology2018
Activation of β-catenin causes defects in embryonic development during maternal-to-zygotic transition in mice.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Discordant effects of maternal age on the human MII oocyte transcriptome.Molecular human reproduction · 2025Article
- Transient suppression of Wnt signaling in poor-quality buffalo oocytes improves their developmental competence.Frontiers in veterinary science · 2023Article
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
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Abstract
The early stage of embryogenesis is an important and complex cell-remodeling event in reproductive biology. To develop into a normal zygote, maternal-to-zygotic transition (MZT) is especially important for both zygotic genome activation (ZGA) and degradation of maternal products during the early stage of embryonic development. β-Catenin has been identified as an important regulator of embryonic development and adult stem cell division via the canonical Wnt/β-catenin signalling pathway. However, the role of activated β-catenin during MZT remains elusive. In the present study, we found that β-catenin is mainly expressed during embryogenesis in the cell membrane from the zygote- to morula-stage embryos but not in MII oocytes. To analyze the function of activated β-catenin during MZT, we conducted a β-catenin activation assay during embryogenesis. Our results indicated that development beyond the two-cell stage was inhibited in zygotes with β-catenin activation. Further analysis showed that activated form of β-catenin protein was increased and the phosphorylated form of β-catenin protein was decreased in culture embryos. Taken together, our study reveals that activation of β-catenin may play a vital role in zygotic development, determining the developmental potential of mouse embryos.
Indexed as
Identifiers
31938364PMC6958268W3028284890What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.