ArticleInternational journal of clinical and experimental pathology2018
MiR-659-3p regulates the progression of chronic myeloid leukemia by targeting SPHK1.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Is Sphingosine Kinase 1 Associated with Hematological Malignancy? A Systematic Review and Meta-Analysis.Asian Pacific journal of cancer prevention : APJCP · 2024Pooled it
- RON receptor tyrosine kinase as a critical determinant in promoting tumorigenic behaviors of bladder cancer cells through regulating MMP12 and HIF-2α pathways.Cell death & disease · 2024Article
- Integrative roles of sphingosine kinase in liver pathophysiology.Toxicological research · 2023Review
- MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation.Journal of personalized medicine · 2022Article
- Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer.Discover oncology · 2021Review
- β-Caryophyllene from Chilli Pepper Inhibits the Proliferation of Non-Small Cell Lung Cancer Cells by Affecting miR-659-3p-Targeted Sphingosine Kinase 1 (SphK1).International journal of general medicine · 2021Article
- Review
- The Tumorigenic Effect of Sphingosine Kinase 1 and Its Potential Therapeutic Target.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Accumulating evidence shows that microRNAs (miRNAs) are significant regulators of multiple cellular processes including chronic myelocytic leukemia (CML). However, the mechanism of miR-659-3p in CML remains unclear. In this study, we aimed to investigate the potential role of miR-659-3p in CML progression. We found that miR-659-3p was down-regulated in CML. The upregulation of miR-659-3p significantly suppressed the proliferation ability, and enhanced the apoptosis capacity of K562 cells. Simultaneously, we found that sphingosine kinase 1 (SPHK1) was up-regulated in CML. MiR-659-3p performed its function through downregulating SPHK1 by binding to its untranslated region (3'-UTR). These results suggested that miR-659-3p, acted as a tumor suppressor, decreased the proliferation ability of K562 cells, and increased the apoptosis capacity of K562 cells. Therefore, our study provided a new theoretical basis of miR-659-3p which may be a promising approach for CML treatment.
Indexed as
Identifiers
31938359PMC6958280W3027590122What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.