ArticleInternational journal of clinical and experimental pathology2018
Decreased expression of TIGIT in NK cells correlates negatively with disease activity in systemic lupus erythematosus.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- PD-1, BTLA and TIGIT as therapeutic targets for rheumatic disease.Nature reviews. Rheumatology · 2026Review
- Reduced TIGITClinical rheumatology · 2025Article
- Anifrolumab for Nonsystemic Cutaneous Lupus Erythematosus: Clinical Experience, Immunologic Insights, and Review of the Literature.Journal of clinical medicine · 2025Article
- Decreased expression of TIGIT on CD14 + monocytes correlates with clinical features and laboratory parameters of patients with primary Sjögren's syndrome.Clinical rheumatology · 2024Article
- Article
- Regulatory NK cells in autoimmune disease.Iranian journal of basic medical sciences · 2023Review
- The Role and Mechanism of Metformin in Inflammatory Diseases.Journal of inflammation research · 2023Review
- PD1, CTLA4 and TIGIT Expression on T and NK Cells in Granulomatous Diseases: Sarcoidosis and ANCA-Associated Vasculitis.International journal of molecular sciences · 2022Article
- Increased TIM-3Clinical and experimental medicine · 2022Article
- Downregulation of TIGIT Expression in FOXP3+Regulatory T Cells in Acute Coronary Syndrome.Journal of inflammation research · 2022Article
- TIGIT as a Promising Therapeutic Target in Autoimmune Diseases.Frontiers in immunology · 2022Review
- The enrichment of neutrophil extracellular traps impair the placentas of systemic lupus erythematosus through accumulating decidual NK cells.Scientific reports · 2021Article
- Checkpoint Molecules in Rheumatology-or the Benefits of Being Exhausted.Current rheumatology reports · 2021Review
- Natural Killer Cells: Potential Biomarkers and Therapeutic Target in Autoimmune Diseases?Frontiers in immunology · 2021Review
- Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well-known that decreased levels of NK cells are found in patients with systemic lupus erythematosus (SLE). However, the mechanism of deregulation of NK cells in SLE is largely unknown. In this study, expression of T-cell immunoreceptor with Ig and immunoreceptor tyrosine-based inhibitory domains (TIGIT) on NK cells was determined by flow cytometry and correlation with markers of autoimmune response, inflammation, disease activity and severity of SLE was further analyzed. Moreover, the function of TIGIT on NK cells in SLE was investigated. We have found that the frequency of TIGIT-expressing NK cells was significantly decreased in SLE patients. The frequency of TIGIT-expressing NK cells in patients with SLE was decreased significantly in subjects with low complement, positive anti-ribosomal RNP (anti-rRNP), and high SLE Disease Activity Index (SLEDAI) score. Furthermore, the frequency of TIGIT-expressing NK cells was significantly increased in SLE patients after regular treatment. In addition, the activation marker CD69, degranulation marker CD107a and cytokine IFN-γ production potential of TIGIT
Indexed as
Identifiers
31938353PMC6958272W3027309505What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.