ArticleInternational journal of clinical and experimental pathology2018
Foci of spindle cell proliferation in multinodular goiter of thyroid: epithelial-mesenchymal transformation or embryonic remnants?
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Spindle lesions in the thyroid: a cytological and histological review.Virchows Archiv : an international journal of pathology · 2025Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Foci of spindle cell proliferation of the thyroid gland have been documented in adenoma and carcinoma, but not much in multinodular goiter. We report a case of spindle cell proliferation detected in multinodular goiter in a 61-year-old female. Histological examination revealed foci of solid area around the normal thyroid follicles. There were two components in this solid area; the first one was composed of epithelial cells with small bland ovoid nuclei and the second one with spindle cells with short spindle-shaped nuclei. Immunohistochemical analysis revealed that the spindle cells were positive for thyroid transcription factor (TTF)-1, Vimentin, CK (AE1/AE3), and negative for p63, etc. The cells with ovoid nuclei had more abundant CK (AE1/AE3) immunoreactivity than those with short spindle-shaped nuclei. In addition, the transition between these two cell types was clearly identified. We hypothesized that this area represented embryonic remnant of developing thyroid gland and therefore evaluated histological features of developing fetal thyroid but this lesion by no means simulated histological features of any developing stages of fetal thyroid gland. The spindle cell foci of thyroid gland could possibly arise from epithelial-mesenchymal transformation of thyroid follicular epithelium in this thyroid gland but it awaits further investigations for clarification.
Indexed as
Identifiers
31938325PMC6958209W3027927048What OpenQuestion holds
Registered trials
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