High expression of HAX-1 protein is associated with tumor growth in papillary thyroid carcinoma.

Yiwei Wang, Xiaochen Xie, Zhenxiang Sun, Jin Zang, Xuren Sun, Shiqiao Peng, Xiaohui Yu, Xiaojie Wang

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In one paragraph

Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact, top 78% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yiwei WangDepartment of Anatomy, Shenyang Medical College Shenyang, Liaoning Province, P. R. China.

Xiaochen XieDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University Shenyang, Liaoning, P. R. China.

Zhenxiang SunDepartment of Anatomy, Shenyang Medical College Shenyang, Liaoning Province, P. R. China.

Jin ZangDepartment of Anatomy, Shenyang Medical College Shenyang, Liaoning Province, P. R. China.

Xuren SunDepartment of Gastroenterology, The First Affiliated Hospital of China Medical University, China Medical University Shenyang, Liaoning, P. R. China.

Shiqiao PengDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University Shenyang, Liaoning, P. R. China.

Xiaohui YuDepartment of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University Shenyang, Liaoning, P. R. China.

Xiaojie WangDepartment of Anatomy, Shenyang Medical College Shenyang, Liaoning Province, P. R. China.

First Hospital of China Medical University · CNShenyang Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Papillary thyroid carcinoma (PTC) is the most common type of endocrine malignancy. HS1-associated protein X-1 (HAX-1) is an anti-apoptotic factor involved in the development of many types of cancer. However, its functional role in human PTC remains unclear. Here we investigated HAX-1 overexpression in human PTC samples and correlated with tumor size and TNM stage. Decreased expression of HAX-1 significantly inhibited proliferation, migration, and invasion in papillary thyroid cancer cell lines TPC1 and K1. Furthermore, we found that down-regulation of HAX-1 induced cell apoptosis. Our results suggest that HAX-1 plays a significant role in regulating the biological behavior in PTC cells and may contribute to PTC target therapy.

Indexed as

apoptosisHAX-1invasionmigrationpapillary thyroid carcinoma

Identifiers

PMID31938315

PMCPMC6958213

OpenAlexW3012931050

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.