ArticleInternational journal of clinical and experimental pathology2018
Differential expression of serine and glycine metabolism-related proteins between follicular neoplasm and Hürthle cell neoplasm.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Molecular network of metabolic reprogramming and precision diagnosis and treatment of hepatocellular carcinoma.Biomarker research · 2025Review
- Reprogramming of Cellular Metabolism and Its Therapeutic Applications in Thyroid Cancer.Metabolites · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to investigate the expression of serine/glycine-related proteins in Hürthle cell neoplasm (HCN) and follicular neoplasm (FN) and to explore its associated implications. Tissue microarrays were constructed with 265 cases of FN (follicular carcinoma [FC]: 112 and follicular adenoma [FA]: 153) and 107 cases of HCN (Hürthle cell carcinoma [HCC]: 27 and Hürthle cell adenoma [HCA]: 80). The serine/glycine-related proteins PHGDH, PSAT1, SHMT1, and GLDC were evaluated using immunohistochemical staining. The expression of SHMT1 and PHGDH was higher in HCN compared to FN (P<0.001 and P=0.048). SHMT1 expression was highest in HCC, followed by HCA, FA, and FC (P<0.001), and PHGDH expression was highest in HCA, followed by HCC, FC, and FA (P=0.041). In FC, SHMT1 negativity was associated with extrathyroidal extension (P=0.019). In univariate analysis, PSAT1 negativity was associated with shorter overall survival (P<0.001). The expression of serine/glycine-related proteins differed between FN and HCN. The expression of both SHMT1 and PHGDH was higher in HCN compared to FN. The clinical implications of this study are that the serine/glycine metabolism pathway could be a possible therapeutic target in HCC.
Indexed as
Identifiers
31938313PMC6958186W3008017029What OpenQuestion holds
Registered trials
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