ArticleInternational journal of clinical and experimental pathology2018
Correlation of microRNA profiles with disease risk and severity of allergic rhinitis.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- MicroRNAs-Are They Possible Markers of Allergic Diseases and Efficient Immunotherapy?International journal of molecular sciences · 2026Review
- Pathophysiological and molecular insights into allergic conjunctivitis: an expanding analysis of immunological endotypes.Frontiers in allergy · 2026Review
- Multi-omics in Allergic Rhinitis: Mechanism Dissection and Precision Medicine.Clinical reviews in allergy & immunology · 2025Review
- MiR-126-5p Down-Regulation Alleviates the Inflammatory Response of Allergic Rhinitis in Children via Inhibiting HIPK2/NF-κB Signaling Pathway.Journal of inflammation research · 2025Article
- MicroRNA-4497 Is Downregulated in Pediatric Allergic Diseases and Suppresses Th2 Inflammation in an Animal Model.International archives of allergy and immunology · 2025Article
- [Progress of allergic rhinitis research based on transcriptome sequencing].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024Review
- IgG from Adult Atopic Dermatitis (AD) Patients Induces Thymic IL-22 Production and CLA Expression on CD4+ T Cells: Possible Epigenetic Implications Mediated by miRNA.International journal of molecular sciences · 2022Article
- Genetics and Epigenetics in Allergic Rhinitis.Genes · 2021Review
- Spotlight on microRNAs in allergy and asthma.Allergy · 2021Review
- MicroRNAs: Potential Biomarkers and Targets of Therapy in Allergic Diseases?Archivum immunologiae et therapiae experimentalis · 2019Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To explore the correlation of microRNA (miRNA) profiles with disease risk and severity in patients with allergic rhinitis (AR). miRNA expression profiles in nasal mucosa samples from 8 AR patients and 8 matched non-atopic controls were detected by microarray. Twelve differentially expressed miRNAs (DEMs) in microarray analysis were further validated in nasal mucosa samples from 48 AR patients and 50 controls by qPCR assay. Individual nasal symptom score (INSS) and total nasal symptom score (TNSS) were used to evaluated the disease severity of AR. AR patients could be distinguished from controls according to the principal component analysis (PCA) plot analysis in the microarray, and 27 down-regulated and 51 up-regulated DEMs were identified by volcano plot. qPCR validation disclosed that miR-126-5p, miR-19a-5p and miR-26a-5p expression was up-regulated in AR patients compared with controls. Multivariate logistic regression displayed that miR-126-5p, miR-19a-5p and miR-26a-5p are independent predictive factors for AR risk, and receiver operating characteristic (ROC) analysis exhibited that the combination of miR-126-5p, miR-19a-5p and miR-26a-5p predicts the risk of AR with a high area under curve (AUC) of 0.866 (95% CI: 0.797-0.936). In addition, expression of miR-126-5p, miR-19a-5p and miR-181c-3p were positively correlated with TNSS. Therefore, miRNA profiles distinguish AR patients from controls and the combination of miR-126-5p, miR-19a-5p and miR-26a-5p could serve as novel biomarker for AR risk.
Indexed as
Identifiers
31938286PMC6958134W3007512015What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.