ArticleInternational journal of clinical and experimental pathology2018
Protective effect of estrogen against calcification in the cartilage endplate.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Comparison of the predictive value of mri-based cervical endplate bone quality (C-EBQ) score and cervical vertebral bone quality (C-VBQ) score for the progression of cervical disc degeneration.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Sex Hormones Attenuate Pro-Inflammatory Gene Expression in Nucleus Pulposus and Annulus Fibrosus Cells in a Cell-Type Specific Manner.JOR spine · 2026Article
- Review
- Influence of gonadectomy and age at gonadectomy on the risk of developing intervertebral disc herniation in French Bulldogs: a retrospective study.Frontiers in veterinary science · 2025Article
- Comparing contribution of bony and cartilaginous endplate changes to intervertebral disc degeneration.Pakistan journal of medical sciences · 2024Article
- Low back pain and osteoarthritis pain: a perspective of estrogen.Bone research · 2023Review
- Neuter status as a risk factor for canine intervertebral disc herniation (IVDH) in dachshunds: a retrospective cohort study.Canine genetics and epidemiology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical studies report that endogenous estrogen depletion is associated with disc degeneration. The present study aimed to investigate the effect and mechanism of estrogen on disc degeneration of the cartilage endplate. Three groups of mice with bilateral ovariectomy + 17β-estradiol injection (OVX + E2 Group), bilateral ovariectomy + vehicle injection (OVX + vehicle), or sham operation + vehicle injection (Sham Group) were included in this study. The mice were sacrificed at 12 weeks and the cartilage endplate (CEP) were harvested. The calcification status was evaluated by Alizarin red staining and RT-PCR, which demonstrated the calcification level of the CEP gradually developed from the Sham Group, OVX + E2, to the OVX + vehicle group. The CEP cells were isolated, cultured, and treated with IL-1β (75 ng/ml) for 24 h, with or without a pretreatment of 17β-E2 for 1 h. RT-PCR analysis of calcification-related genes ALP, OCN, RUNX2, and COL-I were analyzed, and calcification of CEP cells induced by IL-1β was reversed by pretreatment with 17β-E2, in a dose-dependent manner. The protective effect of 17β-E2 was abolished by estrogen receptor antagonist ICI182,780. These results suggest that decreased estrogen level may accelerate degeneration of the cartilage endplate by increasing calcification, which may be induced by IL-1β, in a dose-dependent manner.
Indexed as
Identifiers
31938266PMC6958119W3013937015What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.