ArticleInternational journal of clinical and experimental pathology2018
Leptin can promote mineralization and up-regulate RANKL mRNA expression in osteoblasts from adult female SD rats.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Bone and muscle crosstalk in steroid-induced osteonecrosis of the femoral head: a four-axis pathophysiological framework.Frontiers in immunology · 2026Review
- Association of metabolic score for visceral fat (METS-VF) with lumbar spine bone mineral density in US adults.Scientific reports · 2025Article
- Immunomodulation Using BMP-7 and IL-10 to Enhance the Mineralization Capacity of Bone Progenitor Cells in a Fracture Hematoma-Like Environment.Advanced healthcare materials · 2025Article
- Selected Parameters of Bone Turnover in Neuroendocrine Tumors-A Potential Clinical Use?Journal of clinical medicine · 2023Article
- Advanced applications of strontium-containing biomaterials in bone tissue engineering.Materials today. Bio · 2023Review
- Osteoprotegerin/Receptor Activator of Nuclear Factor-Kappa B Ligand/Receptor Activator of Nuclear Factor-Kappa B Axis in Obesity, Type 2 Diabetes Mellitus, and Nonalcoholic Fatty Liver Disease.Current obesity reports · 2023Review
- At the Crossroads of the Adipocyte and Osteoclast Differentiation Programs: Future Therapeutic Perspectives.International journal of molecular sciences · 2020Review
- Modulation of bone turnover aberration: A target for management of primary osteoporosis in experimental rat model.Heliyon · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoblast-related bone formation is an indispensable part of bone remodeling. Osteoblasts can regulate osteoclast activity through the OPG/RANK/RANKL system. Therefore, studies focus on osteoblast proliferation, differentiation, mineralization, and regulation of osteoclasto genes are important. Leptin is a polypeptide encoded by the obesity gene. In the past, regulatory roles of leptin on sugar and lipid metabolism have been extensively studied. In recent years, leptin has been found to have multiple effects on bone metabolism. However, its role in osteoblasts has not been clarified. In order to investigate the effects of leptin on osteoblasts of adult female SD rats, primary cultured osteoblasts were passaged and divided into control and leptin groups. The effects of leptin on osteoblast proliferation, differentiation, mineralization, and OPG and RANKL mRNA expression were observed. Leptin significantly promoted mineralization of osteoblasts in adult female SD rats, and the mineralized area gradually increased with the increase of leptin concentration. When the concentration of leptin was 100 ng/ml, the mineralized area was the highest (P = 0.001). The expression of RANKL mRNA was also elevated by 10 ng/ml leptin. However, leptin had no significant effect on osteoblast proliferation, secretion of ALP, and expression of OPG mRNA in adult female SD rat osteoblast.
Indexed as
Identifiers
31938260PMC6958118W3026248319What OpenQuestion holds
Registered trials
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