ArticleInternational journal of clinical and experimental pathology2018
Vasculogenic mimicry and expression of ALDH1, Beclin1, and p16 correlate with metastasis and prognosis in oral squamous cell carcinoma.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 10 citations in OpenAlex.
- The Potential Association of CDKN2A and Ki-67 Proteins in View of the Selected Characteristics of Patients with Head and Neck Squamous Cell Carcinoma.Current issues in molecular biology · 2024Article
- Knockdown of LIMD2 inhibits the progression of ovarian carcinoma through ERK1/2 pathway.Molecular biology reports · 2023Article
- Lupeol and Paclitaxel cooperate in hindering hypoxia induced vasculogenic mimicry via suppression of HIF-1α-EphA2-Laminin-5γ2 network in human oral cancer.Journal of cell communication and signaling · 2023Article
- Orchestrated expression of vasculogenic mimicry and laminin-5γ2 is an independent prognostic marker in oral squamous cell carcinoma.International journal of experimental pathology · 2022Article
- Vasculogenic mimicry in head and neck tumors: a narrative review.Translational cancer research · 2021Review
- Prognostic Implications of ALDH1 and Notch1 in Different Subtypes of Oral Cancer.Journal of oncology · 2021Article
- Role of Autophagy in the Microenvironment of Oral Squamous Cell Carcinoma.Frontiers in oncology · 2020Review
- Vascular mimicry: Triggers, molecular interactions and in vivo models.Advances in cancer research · 2020Review
- Expression of aldehyde dehydrogenase 1A1 in oral squamous cell carcinoma and its correlation with clinicopathological parameters.National journal of maxillofacial surgeryArticle
- Cancer stem cell marker ALDH1 and CD44 expression: Independent predictors of survival outcome in oral cancer patients.National journal of maxillofacial surgeryArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVasculogenic mimicry (VM) is a new blood supply in malignant tumors and has long been considered as an effective factor in the metastasis and prognosis of many cancers. ALDH1 (a marker of cancer stem cells), Beclin1 (a biomarker of autophagy) and p16 (a suppressor gene of tumor) are all useful predictive factors for many cancer metastases. However, the prognostic and metastatic value of VM, ALDH1, Beclin1, or p16 in oral squamous cell carcinoma (OSCC) is unclear. In this study, we analyzed correlations among VM, ALDH1, Beclin1, and p16 in OSCC, and their respective associations with clinicopathological parameters and survival in OSCC.
methodsPositive rates of VM, ALDH1, Beclin1, and p16 in 186 whole OSCC specimens were detected by immunohistochemical and histochemical staining. Patients' clinical information was also collected.
resultsPositive rates of VM, ALDH1, and Beclin1 were significantly higher, and levels of p16 were significantly lower in OSCC than in normal oral tissues. Positive rates of VM, ALDH1, and Beclin1 were positively associated with tumor grade, primary tumor (pT), lymph node metastasis (LNM), and tumor-node-metastasis (TNM) stage, and inversely with patients overall survival (OS) time. Levels of p16 was negatively associated with grade, pT, LNM, and TNM stage, and positively associated with smoking and alcohol. The p16+ subgroup had significantly longer OS time than did the p16- subgroup. In multivariate analysis, high ALDH1, VM, Beclin1 levels, tumor grade, pT, LNM, TNM stage, and low p16 levels were potential to be independent prognostic factors for OS time in OSCC patients.
conclusionsVM, and the expression of ALDH1, Beclin1, and p16 represent promising markers for metastasis and prognosis, and potential therapeutic targets for OSCC.
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31938259PMC6958093W3027642793What OpenQuestion holds
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