ArticleInternational journal of clinical and experimental pathology2018
MicroRNA-21 promotes cell proliferation by targeting tumor suppressor TET1 in colorectal cancer.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- The multifaceted role of microRNAs in colorectal cancer: pathogenesis and therapeutic implications.Non-coding RNA research · 2025Review
- TET1: The epigenetic architect of clinical disease progression.Genes & diseases · 2025Review
- The effects of intracellular and exosomal ncRNAs on cancer progression.Cancer gene therapy · 2023Review
- MiR-183-5p promotes renal cell carcinoma metastasis by targeting TET1.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) regulate gene expression by binding to mRNA, and can function as oncogenes or tumor suppressors depending on the target. TET1 acts as tumor-suppressor, which is downregulated in colorectal cancers (CRC) and inhibits cell growth. However, it has not been studied as to whether miRNAs, suppressing target expression by binding to the 3'UTR, regulate TET1 expression in colorectal cancers. Here, our study found that miR-21 has matching sites on TET1. In the tumor tissue samples from 50 patients with CRC, the expression of miR-21 was upregulated compared with that in adjacent tissue samples while the expression of TET1 showed a significant decrease. In addition, miR-21 expression was negatively correlated with the expression of TET1. Moreover, low expression of miR-21 by the transfection of colorectal cancer cell lines with miR-21 inhibitors, the effect on TET1 expression was opposite to the change of miR-21 expression. Furthermore, our results indicated that miR-21 promoted proliferation of colorectal cancer cells by targeting TET1. These findings may provide a theoretical basis for clarifying the physiological and pathological role of miR-21 in colorectal cancer.
Indexed as
Identifiers
31938241PMC6958103W3026262193What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.