ArticleInternational journal of clinical and experimental pathology2018
JUB induces epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway in hepatocellular carcinoma cells.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Role of Sulfur Metabolism Gene and High-Sulfur Gene Expression in Wool Growth Regulation in the Cashmere Goat.Frontiers in genetics · 2021Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epithelial-mesenchymal transition (EMT) is a key process involving acquisition of metastatic potential for cancer cells. Hepatocellular carcinoma (HCC) is a common cancer where metastasis is linked to patient survival. JUB has been reported to be involved in several physiological processes, however, pathological roles of JUB in tumor metastasis have been poorly studied. Here, we report that JUB is highly upregulated in clinical specimens and HCC cell lines. Through gain- and loss-of-function studies, JUB was demonstrated to facilitate HCC cell EMT. We found that JUB expression was upregulated in the HCC tissues compared to borderline or benign tissues. Experimental EMT induced by JUB plasmid transfection proved that JUB protein overexpression could enhance transwell migration ability and significantly upregulate mesenchymal marker proteins, N-cadherin and concurrently downregulate the epithelial marker E-cadherin. Subsequently, through Western blot assay, we found that JUB could activate the Wnt-signaling component β-catenin in the nuclei. Our findings revealed that JUB might be a key molecule regulating EMT through modulation of the Wnt/β-catenin signaling pathway.
Indexed as
Identifiers
31938233PMC6958140W3026106462What OpenQuestion holds
Registered trials
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