ArticleInternational journal of clinical and experimental pathology2018
miR-135a-5p affects adipogenic differentiation of human adipose-derived mesenchymal stem cellsby promoting the Hippo signaling pathway.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 7 citations in OpenAlex.
- Time-resolved Hippo-YAP transcript and microRNA responses to imatinib in K562 chronic myeloid leukemia cells with exploratory analysis of CD34⁺ progenitor transcriptomes.Molecular biology reports · 2026Article
- Whispers of Growth: The Impact of MicroRNA on the Proliferation Potential of Adipose-Derived Stem Cells-A Review.BioMed research international · 2026Review
- YAP1 promotes adipogenesis by regulating the negative feedback mechanism of the Hippo signaling pathway via LATS2.Zoological research · 2025Article
- Role of miRNA-mRNA Interactome in Pathophysiology of Arrhythmogenic Cardiomyopathy.Biomedicines · 2024Article
- Identification of circRNA Expression Profiles in BMSCs from Glucocorticoid-Induced Osteoporosis Model.Stem cells international · 2022Article
- Inhibition of miR-135a-5p attenuates vascular smooth muscle cell proliferation and vascular remodeling in hypertensive rats.Acta pharmacologica Sinica · 2021Article
- LncRNA FOXD3-AS1/miR-135a-5p function in nasopharyngeal carcinoma cells.Open medicine (Warsaw, Poland) · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) have been extensively studied and play a regulatory role during adipogenesis. Specifically, many miRNAs participate in regulation of mesenchymal stem cell (MSC) differentiation into adipogenic and osteogenic lineages. However, the regulatory mechanisms of miR-135a-5p in the Hippo signaling pathway during adipogenesis need to be explored. In this study, we observed that miR-135a-5p promotes adipogenesis of human adipose-derived MSCs (hADMSCs). miR-135a-5p was overexpressed in adipocytes compared to hADMSCs and further upregulation of miR-135a-5p promoted proliferation and adipogenesis of hADMSCs. In contrast, miR-135a-5p reduction inhibited these processes. Luciferase activity detection and Western blotting confirmed that overexpressed miR-135a-5p had the ability to upregulate the HIPPO signaling pathway. Subsequently, we observed that miR-135a-5p is targeted to key negative regulators in the HIPPO signaling pathway, including MOB kinase activator 1B (MOB1B) and large tumor suppressor 1 (LATS1). Moreover, suppression of LATS1 and MOB1B upregulated the activity of TEAD. In conclusion, we have verified that miR-135a-5p plays an active role in adipogenesis by targeting LATS1 and MOB1B expression, thereby enhancing the HIPPO signaling pathway.
Indexed as
Identifiers
31938230PMC6958094W3027208920What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.