ArticleInternational journal of clinical and experimental pathology2018
LncRNA H19 promotes proliferation and invasion in A375 human melanoma cell line.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Gene Expression Patterns in a Congenital Neurocristic Hamartoma With Multiple Proliferative Nodules.Journal of cutaneous pathology · 2025Article
- Transcriptional network constituted of CBP, Ku70, NOX2, and BAX prevents the cell death of necrosis, paraptosis, and apoptosis in human melanoma.Cell death discovery · 2021Article
- A Non-Coding RNA Network Involved in KSHV Tumorigenesis.Frontiers in oncology · 2021Article
- LncRNA H19: A novel oncogene in multiple cancers.International journal of biological sciences · 2021Review
- Long Noncoding RNA H19: A Novel Therapeutic Target Emerging in OncologyFrontiers in cell and developmental biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the effects of H19 gene on the proliferation and invasion of A375 human melanoma cells.
methodsA375 cells were infected with a lentiviral vector overexpressing H19 or transfected with H19 RNA interference constructs. The proliferation and invasion of A375/H19
resultsThe optical density value of A375/H19
conclusionsThe results of this study showed that H19 overexpression promoted the proliferation, invasion, and growth of A375 cells. In addition, it upregulated the mRNA and protein expression levels of MMP2 and MMP9, which in turn promoted cell invasion. Furthermore, H19 appeared to enhance Akt phosphorylation, directly suppress E-cadherin, and upregulate Slug expression to promote A375 cell invasion.
Indexed as
Identifiers
31938202PMC6958159W3018650856What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.