Evidence map›Paper›PMID 31938187›Full record

ArticleInternational journal of clinical and experimental pathology2018

Differential expression of serum microRNAs in glucocorticoid-resistant patients with ulcerative colitis.

Juan Luo, Yijie Wang, Danfeng Lan, Junkun Niu, Jiarong Miao, Xiangqian Dong, Gang Yang, Fengrui Zhang, Yu Cao, Kunhua Wang and 1 more

Abstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Role of microRNAs in Inflammatory Bowel Disease.International journal of molecular sciences · 2025
    Review
  5. Review
  6. Review
  7. Article
  8. The beneficial effects ofAnnals of translational medicine · 2023
    Article
  9. Review
  10. Article
  11. MicroRNAs in Inflammatory Bowel Disease and Its Complications.International journal of molecular sciences · 2022
    Review
  12. Article
  13. Review
  14. Review
  15. Role of Autophagy and Apoptosis in Acute Lymphoblastic Leukemia.Cancer control : journal of the Moffitt Cancer Center
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Juan LuoDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease Kunming , China.
Yijie WangDepartment of Critical Care Medicine, The First Affiliated Hospital of Kunming Medical University Kunming, China.
Danfeng LanDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease Kunming , China.
Junkun NiuDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease Kunming , China.
Jiarong MiaoDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease Kunming , China.
Xiangqian DongDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease Kunming , China.
Gang YangDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease Kunming , China.
Fengrui ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease Kunming , China.
Yu CaoDepartment of Cardiac Surgery, The First People's Hospital of Yunnan Province Kunming, China.
Kunhua WangDepartment of General Surgery, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease Kunming , China.
Yinglei MiaoDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Yunnan Institute of Digestive Disease Kunming , China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammatory bowel disease (IBD) includes ulcerative colitis (UC) and Crohn's disease (CD). Glucocorticoids (GCs) are the most effective treatment for moderate to severe active UC. However, one-third of patients are not sensitive to GCs (i.e., they are GC resistant). The mechanism of GC resistance in IBD is unknown, and it remains unclear how to predict resistance in IBD patients. This study aimed to explore the possible correlation between miRNA expression and variability in GC-resistant and GC-sensitive patients with ulcerative colitis. A comparative serum microRNA analysis in GC-resistant and GC-sensitive patients with ulcerative colitis was conducted by microarray. Differential microRNA expression was further validated in serum samples by quantitative real-time PCR. We found that downregulated microRNAs had a significant correlation with several signal transduction pathways (the PI3K-Akt and MAPK signaling pathways) and target genes (

Indexed as

glucocorticoid resistanceMicroRNAmolecular mechanismUlcerative colitis

Identifiers

PMID31938187
PMCPMC6958021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.