ArticleInternational journal of clinical and experimental pathology2018
Decreased CCDC19 is correlated with unfavorable outcome in lung squamous cell carcinoma.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
aimsThe chief aim of this study was to correlate expression of the nasopharyngeal epithelium protein (CCDC19) with clinicopathological characteristics and survival prognosis in lung squamous cancer patients. METHODS AND
resultsUsing real-time PCR, we detected the mRNA expression of CCDC19 in lung squamous cell carcinoma tissues and lung tissue. CCDC19 mRNA expression was confirmed to be downregulated compared to normal lung tissues. Furthermore, we analyzed CCDC19 protein expression using immunohistochemical analysis and observed CCDC19 protein in 136 paraffin-embedded squamous cell carcinoma tissues and 47normal paraffin-embedded lung tissues. CCDC19 protein was downregulated in lung squamous carcinoma, but overexpressed in normal lung tissues. Furthermore, correlation between the level of CCDC19 expression and clinical features, including survival prognosis was analyzed. Decreased expression of CCDC19 protein was significantly associated with N stage (
conclusionsOur findings demonstrate that decreased CCDC19 expression facilitates disease progression and poor outcome in lung squamous cell carcinoma patients.
Indexed as
Identifiers
31938168PMC6958016W3026324031What OpenQuestion holds
Registered trials
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