Evidence map›Paper›PMID 31938157›Full record

ArticleInternational journal of clinical and experimental pathology2018

Negative nuclear expression of CDKL2 correlates with disease progression and poor prognosis of glioma.

Renhui Yi, Shaochun Yang, Ersheng Wen, Zheng Hu, Hao Long, Yu Zeng, Xizhao Wang, Xiaoyu Huang, Yuanyuan Liao, Muyun Luo and 7 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Renhui YiGannan Medical University Ganzhou, Jiangxi, P. R. China.
Shaochun YangDepartment of Neurosurgery, First Affiliated Hospital of Gannan Medical University Ganzhou, Jiangxi, P. R. China.
Ersheng WenGannan Medical University Ganzhou, Jiangxi, P. R. China.
Zheng HuDepartment of Neurosurgery, First Affiliated Hospital of Gannan Medical University Ganzhou, Jiangxi, P. R. China.
Hao LongDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong, P. R. China.
Yu ZengDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong, P. R. China.
Xizhao WangDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong, P. R. China.
Xiaoyu HuangGannan Medical University Ganzhou, Jiangxi, P. R. China.
Yuanyuan LiaoDepartment of Ultrasonography, First Affiliated Hospital of Gannan Medical University Ganzhou, Jiangxi, P. R. China.
Muyun LuoDepartment of Neurosurgery, First Affiliated Hospital of Gannan Medical University Ganzhou, Jiangxi, P. R. China.
Jizhou WangDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong, P. R. China.
Mingfeng ZhouDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong, P. R. China.
Wen WangDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong, P. R. China.
Anqi XuDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong, P. R. China.
Jie LinDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong, P. R. China.
Zhiyong WuDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong, P. R. China.
Ye SongDepartment of Neurosurgery, Nanfang Hospital, Southern Medical University Guangzhou, Guangdong, P. R. China.
Nanfang Hospital · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThis study aimed to investigate the nuclear expression status of cyclin dependent kinase like 2 (CDKL2) in glioma and its correlation with the characteristics of clinical pathology, including patient survival. METHODS AND

resultsIn the present study, the expression of CDKL2 mRNA was detected by real-time QPCR in freshly collected glioma and para-carcinoma tissues. Moreover, immunohistochemistry was used to identified nuclear expression of CDKL2, and the characteristics of clinical pathology from glioma cases (n = 144) and non-cancerous brain tissues (n = 32) were counted. Low mRNA and nuclear protein expression of CDKL2 was observed in glioma tissues compared to non-cancerous tissues. Glioma patients with negative nuclear expression of CDKL2 were correlated with histologic type, clinical World Health Organization (WHO) grade, tumor location, and KI-67 expression status. Negative nuclear expression of CDKL2 in glioma patients predicted an observably shorter overall survival time than did positive expression. However, as demonstrated by multivariate analysis, nuclear expression of CDKL2 was not an independent prognostic biomarker for the survival of patients with glioma.

conclusionsOur study indicated that negative nuclear expression of CDKL2 may represent a potential unfavorable marker for progression and poor prognostic in glioma.

Indexed as

CDKL2 nuclearGliomaprognosis

Identifiers

PMID31938157
PMCPMC6958001
OpenAlexW3027544042

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.