ArticleInternational journal of clinical and experimental pathology2018
Hsp27 reduces cold ischemia-reperfusion injury in heart transplantation through regulation of NF-κB and PUMA signaling.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Empagliflozin Supplementation in Cardioplegic Solution Improves Donor Heart Preservation by Maintaining Mitochondrial Homeostasis.Cardiovascular drugs and therapy · 2026Article
- MK5 Regulates Microglial Activation and Neuroinflammation in Experimental Stroke Models.CNS neuroscience & therapeutics · 2025Article
- Conditioned medium from adipose-derived stem cells attenuates ischemia/reperfusion-induced cardiac injury through the microRNA-221/222/PUMA/ETS-1 pathway.Theranostics · 2021Article
- Reductive Stress-Induced Mitochondrial Dysfunction and Cardiomyopathy.Oxidative medicine and cellular longevity · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveGlobal myocardial ischemia-reperfusion (I/R) injury after heart transplantation is believed to impair graft function and aggravate episodes of both acute and chronic rejection. The 27-kDa heat shock protein (Hsp27) has a potent ability to alleviate I/R after cardiac transplantation. The aim of this study was to investigate the anti-I/R injury effect of Hsp27 to elucidate the underling mechanisms.
methodsHeart grafts from BALB/c mice were preserved in University of Wisconsin (UW) solution (control) or UW solution containing pAAV-Hsp27 (Hsp27 solution) at 4°C for 48 h and subsequently transplanted into syngeneic recipients for 72 h. The heart grafts were then collected for histopathological and gene expression analyses. An
resultsCold I/R caused severe morphologic myocardial injury of heart grafts from wild type C57BL/c mice, whereas grafts from Hsp27 preservation showed less damage as demonstrated by decreased cell apoptosis/death and the preservation of the normal structure of the heart. Hsp27 inhibited I/R-induced injury as indicated by the reduction in cardiac troponin I activities and decreased cardiac tissue levels of the proinflammatory factors TNF-α, IL-1β, and IL-6. Hsp27 was further demonstrated to significantly inhibit nuclear translocation of p65 and p53 upregulated modulator of apoptosis (PUMA) expression.
conclusionsThese results suggested that the cardioprotective effect of Hsp27 could be due to the suppression of the myocardial inflammatory response and apoptosis by blocking the NF-κB-dependent pro-inflammatory and NF-κB-dependent PUMA signaling pathways.
Indexed as
Identifiers
31938111PMC6957943W3004793700What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.