Immediate early response gene 5 promotes irradiation combined with cisplatin-induced apoptosis in HeLa cells.

Ming Tian, Xin-Ping Yu, Ping-Kun Zhou, Yu-Mei Wu

Open access · greenAbstract read

In one paragraph

Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.2field-weighted citation impact, top 35% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

IER5 Negatively Regulates Cdc25B Expression in HeLa Cells After Gamma Ray Irradiation.BioMed research international · 2025
Article
Novel role of PAF1 in attenuating radiosensitivity in cervical cancer by inhibiting IER5 transcription.Radiation oncology (London, England) · 2020
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ming TianDepartment of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University Beijing, China.

Xin-Ping YuDepartment of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University Beijing, China.

Ping-Kun ZhouDepartment of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine Beijing, China.

Yu-Mei WuDepartment of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University Beijing, China.

Beijing Obstetrics and Gynecology Hospital · CNCapital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to explore the action and mechanism of immediate early response gene 5 (IER5) on the apoptosis induced by irradiation combined with cisplatin in HeLa cells. The IER5 gene was knocked down using IER5-specific small interfering (si)RNA to generate HeLa cells stably expressing low levels of IER5 (HeLa-siIER5). Apoptosis was induced by

Indexed as

apoptosiscervical cancercisplatinIER5γ-radiation

Identifiers

PMID31938109

PMCPMC6957955

OpenAlexW3026643605

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.