ArticleInternational journal of clinical and experimental pathology2018
siRNA directed against Annexin II receptor inhibits HeLa cell proliferation, migration and invasion and induces apoptosis via suppressing ERK1/2 and Akt signaling pathways.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 1 citations in OpenAlex.
- Transcriptome sequencing (RNA-Seq) reveals non-coding pseudogene CDC27P9 role in cervical cancer.Apoptosis : an international journal on programmed cell death · 2026Article
- Identification of Abundant and Functional dodecaRNAs (doRNAs) Derived from Ribosomal RNA.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Annexin II receptor (AXIIR) was originally identified as a cell surface receptor for Annexin II and was shown to be involved in the development and progression of multiple cancers, but little was known about its role in cervical cancer. The aim of our study was to investigate the role and the plausible molecular mechanism of AXIIR in regulating apoptosis, invasion and migration of cervical cancer cells. siRNA targeting AXIIR was chemical synthesized and transfected into HeLa cells which with non-specific siRNA tranfection used as a negative control. Cell proliferation, cell migration, cell invasion and cell apoptosis assay were measured by CCK-8, wound healing assay, Transwell invasion assay and flow cytometry, respectively. Tumor-related protein and signaling pathway were also measured by real-time quantitative PCR and western blot assay to investigate the molecular mechanism of AXIIR involved in regulating HeLa cells. Our data showed that AXIIR siRNA significantly inhibited HeLa cell viability and induced cell apoptosis by increases in Caspase-3/-8/-9 mRNA and protein expression, and inhibit HeLa cell migration and invasion by decreased MMP-2/-9 mRNA and protein expression. AXIIR siRNA could also significantly down-regulate Akt, p-Akt, ERK1/2 and p-ERK1/2 expression. In conclusion, AXIIR is of great importance for regulatingcell viability, migration, invasion and apoptosis
Indexed as
Identifiers
31938090PMC6957953W3026684818What OpenQuestion holds
Registered trials
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