ArticleInternational journal of clinical and experimental pathology2018
RNA interfering of CXCR4 inhibits the adhesion, invasion, and tumorigenicity of acute monocytic leukemic cells
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the effect of CXCR4 gene expressing on the proliferation, adhesion, and invasion of human monocytic leukemic cell line SHI-1 and its tumorigenic capacity in nude mouse. The SHI-1 cells were firstly infected with the rescued recombinant lentivirus to establish SHI-1/CXCR4i cell line. The expression of CXCR4, MMP-2 and MMP-9 in the SHI-1/CXCR4i cell was determined by real time quantitative PCR and flow cytometry. MTT assay was performed to detect the SHI-1/CXCR4i cell proliferative rate. The co-culture system of the leukemia cells with bone marrow stromal cells was utilized to detect the adhesive and migratory ability of SHI-1/CXCR4i cell. The nude mouse was subcutaneously inoculated with both cell lines, and then used to evaluate the growth ability of leukemia cells without CXCR4 expressing. The expression of CXCR4 mRNA in established SHI-1/CXCR4i cells decreased by 76% comparing with that in SHI-1/NC cells, which were infected with negative control virus. The proliferative rate of the SHI-1/CXCR4i cells
Indexed as
Identifiers
31938088PMC6957952W3027424621What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.