ArticleInternational journal of clinical and experimental pathology2018
Synergistic effect of estradiol and testosterone protects against IL-6-inducedcardiomyocyte apoptosismediated by TGF-β1.
Article in International journal of clinical and experimental pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBasic studies have verified that estradiol or androgen is influential on cardioprotection, howeversynergistic effects of estradiol and testosterone on heart failure (HF) are still unknown. This study aimed to evaluate the association among sex hormones and heart failure risk factors.
methods142 controls and 196 patients with HF were selected for this study. Serum levels of estradiol, testosterone, Brain natriuretic peptide precursor, transforming growth factor-β1, β2 and β3, lipid-lipoprotein profile, glucose, high-sensitivity C-reactive protein, serum creatinine, microglobulin, uric acid, alanine aminotransferase, aspartate aminotransferase were determined. H9c2 cardiac myocytes were used to investigate the effect of estradiol and testosterone on cardiomyocytes apoptotic involved in TGF-β1. Signaling pathway of caspase 3, Bax, Bcl-2, caspase 8 and TGF-β was determined during the IL-6 induced apoptotic.
resultsFirst, our results showed that compared with the control, the E2/T ratio decreased from 6.32±9.89 to 3.43±3.16 (P <0.001) in female, from 4.00±8.14 to 7.80±11.35 (P<0.001) in male with heart failure, and the level of TGF-β1 increased. What's more, these changes were favorably associated with the cardiac function classification. Univariate and multivariate logistic regression analysis showed that serum E2/T ratio, TGF-β1 and NT-proBNP were independent risk factor in heart failure patients. Second, we found that TGF-β1 was upregulated in rat H9c2 cardiomyocyte induced by IL-6, and TGF-β1 regulates the apoptosis of rat H9c2 cardiomyocyte. Furthermore, we verified the beneficial effects of the defined appropriate E2/T ratio on cardiomyocyte apoptotic mediated by TGF-β1.
conclusionThe balance of the serum E2/T ratio was broken in patients with heart failure, and an imbalanced E2/T ratio showed a strong association with heart failure risk factors, and E2 combined with T play a synergistic effect on anti-apoptosis involved in TGF-β1.
Indexed as
Identifiers
31938083PMC6957934W3027949430What OpenQuestion holds
Registered trials
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