Evidence map›Paper›PMID 31938068›Full record

ArticleTheranostics2020

Lipid oversupply induces CD36 sarcolemmal translocation via dual modulation of PKCζ and TBC1D1: an early event prior to insulin resistance.

Bili Zhu, Ming-Yue Li, Quanming Lin, Zhicheng Liang, Qihang Xin, Menghuan Wang, Zhendan He, Xiaomei Wang, Xuli Wu, George G Chen and 3 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. CD36: bridging metabolism, inflammation, and reproduction.npj metabolic health and disease · 2026
    Review
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  14. [CD36 gene deletion reduces muscle insulin sensitivity in mice by up-regulating PTP1B expression].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  15. Effects of Lipid Overload on Heart in Metabolic Diseases.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Bili ZhuGuangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Physiology, Health Science Center, School of Medicine, Shenzhen University, Shenzhen, China.
Ming-Yue LiDepartment of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Quanming LinGuangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Physiology, Health Science Center, School of Medicine, Shenzhen University, Shenzhen, China.
Zhicheng LiangGuangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Physiology, Health Science Center, School of Medicine, Shenzhen University, Shenzhen, China.
Qihang XinGuangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Physiology, Health Science Center, School of Medicine, Shenzhen University, Shenzhen, China.
Menghuan WangGuangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Physiology, Health Science Center, School of Medicine, Shenzhen University, Shenzhen, China.
Zhendan HeKey Laboratory of Natural Small Molecular Drugs, School of Pharmacy, Shenzhen University, Shenzhen, China.
Xiaomei WangGuangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Physiology, Health Science Center, School of Medicine, Shenzhen University, Shenzhen, China.
Xuli WuSchool of Public Health, Shenzhen University, Shenzhen, China.
George G ChenDepartment of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
Peter Cy TongJockey Club School of Public Health and Primary Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Weizhen ZhangDepartment of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China.
Li-Zhong LiuGuangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Physiology, Health Science Center, School of Medicine, Shenzhen University, Shenzhen, China.
Shenzhen University · CNChinese University of Hong Kong · CNPeking University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipid oversupply may induce CD36 sarcolemmal translocation to facilitate fatty acid transport, which in turn causes dyslipidemia and type 2 diabetes. However, the underlying mechanisms of CD36 redistribution are still yet to be unraveled.

Indexed as

Insulin ResistanceAnimalsCD36 AntigensCell LineDiabetes Mellitus, Type 2Diet, High-FatFatty AcidsGTPase-Activating ProteinsMaleMiceMice, Inbred C57BLMuscle CellsProtein Kinase C-thetaProtein TransportRatsSarcolemmaCD36 AntigensCd36 protein, ratFatty AcidsGTPase-Activating ProteinsPrkcq protein, mouseProtein Kinase C-thetaTbc1d1 protein, mouseCD36fatty acidPKCζTBC1D1

Identifiers

PMID31938068
PMCPMC6956797
OpenAlexW2997929299

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.