Evidence map›Paper›PMID 31938059›Full record

ArticleTheranostics2020

Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy.

Dandan Liu, Yingcai Hong, Yaping Li, Chong Hu, Tak-Chun Yip, Wai-Kin Yu, Yu Zhu, Chi-Chun Fong, Weimao Wang, Siu-Kie Au and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 126 citations in OpenAlex.

  1. Review
  2. Co-Doped (NaChemistryOpen · 2026
    Article
  3. Article
  4. Magnetic nanoparticles for cancer theranostics.Biomedical physics & engineering express · 2026
    Review
  5. Magnetic nanoparticles as promising materials for the future of medicine.Journal of materials science. Materials in medicine · 2026
    Review
  6. Review
  7. EMT and cancer stem cells: Drivers of therapy resistance and promising therapeutic targets.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy · 2025
    Review
  8. Review
  9. Review
  10. Advanced drug delivery platforms target cancer stem cells.Asian journal of pharmaceutical sciences · 2025
    Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Advances in magnetic induction hyperthermia.Frontiers in bioengineering and biotechnology · 2024
    Review
  19. Smart nanoparticles for cancer therapy.Signal transduction and targeted therapy · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Dandan LiuDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
Yingcai HongDepartment of Thoracic Surgery, Shenzhen People's Hospital, the Second Clinical Medical College of Jinan University, Shenzhen 510000, China.
Yaping LiDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
Chong HuDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
Tak-Chun YipDepartment of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China.
Wai-Kin YuDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
Yu ZhuDepartment of Oncology, Peking University Shenzhen Hospital, Shenzhen 518036, China.
Chi-Chun FongDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
Weimao WangDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
Siu-Kie AuDepartment of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China.
Shubin WangDepartment of Oncology, Peking University Shenzhen Hospital, Shenzhen 518036, China.
Mengsu YangDepartment of Biomedical Sciences, City University of Hong Kong, Hong Kong, China.
City University of Hong Kong · HKCity University of Hong Kong, Shenzhen Research Institute · CNJinan University · CNPeking University Shenzhen Hospital · CNQueen Elizabeth Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer stem cells (CSCs) have been implicated in cancer recurrence and therapy resistance. Therefore, a CSC-targeted therapy that disrupts the maintenance and survival of CSCs may offer an effective approach in killing tumor cells in primary tumors and preventing the metastasis caused by CSCs. Nanoparticles (NPs)-based thermotherapy and/or chemotherapy are promising therapeutic methods for cancer treatment.

Indexed as

Hyperthermia, InducedAnimalsAntineoplastic AgentsCell Line, TumorCombined Modality TherapyDrug CarriersHumansLung NeoplasmsMagnetite NanoparticlesMesenchymal Stem CellsMiceMice, Inbred BALB CMice, NudeNeoplasm Recurrence, LocalNeoplastic Stem CellsSmall Cell Lung CarcinomaAntineoplastic AgentsDrug CarriersMagnetite NanoparticlesAlternating magnetic fieldLung cancer stem cellMultifunctional nanoparticleThermotherapy and chemotherapy

Identifiers

PMID31938059
PMCPMC6956796
OpenAlexW2997535973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.