Evidence map›Paper›PMID 31938013›Full record

ArticleStatistica Sinica2019

Marginal screening for high-dimensional predictors of survival outcomes.

Tzu-Jung Huang, Ian W McKeague, Min Qian

Abstract read
In one paragraph

Article in Statistica Sinica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Post-selection inference for high-dimensional mediation analysis with survival outcomes.Scandinavian journal of statistics, theory and applications · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tzu-Jung HuangDepartment of Biostatistics, Columbia University.
Ian W McKeagueDepartment of Biostatistics, Columbia University.
Min QianDepartment of Biostatistics, Columbia University.
Columbia University · US

Funding

Post-selection inference and trajectory analysisR01GM095722 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MCKEAGUE, IAN WRAY · 2011 to 2018
$1.5M
Building Multistage Treatment Regimens for Depression after Acute Coronary SyndromeSyndromeR21MH108999 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QIAN, MIN · 2016 to 2017
$440k
NIGMS NIH HHS R01 GM095722NIMH NIH HHS R21 MH108999
6 · The paper itself

Abstract

This study develops a marginal screening test to detect the presence of significant predictors for a right-censored time-to-event outcome under a high-dimensional accelerated failure time (AFT) model. Establishing a rigorous screening test in this setting is challenging, because of the right censoring and the post-selection inference. In the latter case, an implicit variable selection step needs to be included to avoid inflating the Type-I error. A prior study solved this problem by constructing an adaptive resampling test under an ordinary linear regression. To accommodate right censoring, we develop a new approach based on a maximally selected Koul-Susarla-Van Ryzin estimator from a marginal AFT working model. A regularized bootstrap method is used to calibrate the test. Our test is more powerful and less conservative than both a Bonferroni correction of the marginal tests and other competing methods. The proposed method is evaluated in simulation studies and applied to two real data sets.

Indexed as

Accelerated failure time modelBootstrapFamily-wise error rateInverse probability weightingMultiple testingPost-selection inference

Identifiers

PMID31938013
PMCPMC6959482
OpenAlexW2811202270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.