Evidence map›Paper›PMID 31937925›Full record

ArticleBritish journal of cancer2020

MRI-based radiomics model for preoperative prediction of 5-year survival in patients with hepatocellular carcinoma.

Xiao-Hang Wang, Liu-Hua Long, Yong Cui, Angela Y Jia, Xiang-Gao Zhu, Hong-Zhi Wang, Zhi Wang, Chong-Ming Zhan, Zhao-Hai Wang, Wei-Hu Wang

Abstract readMulticenter Study
In one paragraph

Article in British journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

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  13. MRI Imaging Biomarkers for Prognostication of Hepatocellular Carcinoma.Journal of the Korean Society of Radiology · 2025
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Xiao-Hang WangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
Liu-Hua LongKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
Yong CuiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiology, Peking University Cancer Hospital and Institute, Beijing, China.
Angela Y JiaDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Xiang-Gao ZhuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
Hong-Zhi WangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
Zhi WangBlot Info & Tech (Beijing) Co. Ltd, Beijing, China.
Chong-Ming ZhanBlot Info & Tech (Beijing) Co. Ltd, Beijing, China.
Zhao-Hai Wang *Department of Hepatobiliary Surgery, The Fifth Medical Center of Chinese PLA General Hospital, Beijing Institute of Infectious Diseases, Beijing, China. pla302wzh@163.com.
Wei-Hu Wang *Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China. wangweihu88@163.com.

Funding

Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support XMLX201842Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) 7182028
6 · The paper itself

Abstract

backgroundRecurrence is the major cause of mortality in patients with resected HCC. However, without a standard approach to evaluate prognosis, it is difficult to select candidates for additional therapy.

methodsA total of 201 patients with HCC who were followed up for at least 5 years after curative hepatectomy were enrolled in this retrospective, multicentre study. A total of 3144 radiomics features were extracted from preoperative MRI. The random forest method was used for radiomics signature building, and five-fold cross-validation was applied. A radiomics model incorporating the radiomics signature and clinical risk factors was developed.

resultsPatients were divided into survivor (n = 97) and non-survivor (n = 104) groups based on the 5-year survival after surgery. The 30 most survival-related radiomics features were selected for the radiomics signature. Preoperative AFP and AST were integrated into the model as independent clinical risk factors. The model demonstrated good calibration and satisfactory discrimination, with a mean AUC of 0.9804 and 0.7578 in the training and validation sets, respectively.

conclusionsThis radiomics model is a valid method to predict 5-year survival in patients with HCC and may be used to identify patients for clinical trials of perioperative therapies and for additional surveillance.

Indexed as

Carcinoma, HepatocellularFemaleHumansLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedPreoperative ExerciseRetrospective Studies

Identifiers

PMID31937925
PMCPMC7109104

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.