ArticleBritish journal of cancer2020
Pre-operative cellular dissociation grading in biopsies is highly predictive of post-operative tumour stage and patient outcome in head and neck squamous cell carcinoma.
Article in British journal of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 19 citations in OpenAlex.
- Tumor budding and lymphovascular invasion as prognostic factors in p16-positive oropharyngeal squamous cell carcinomas.British journal of cancer · 2025Article
- Web-based prognostic tools for oral tongue cancer: An analysis of online predictors.Oral diseases · 2024Article
- Tumor-stroma contact ratio - a novel predictive factor for tumor response to chemoradiotherapy in locally advanced oropharyngeal cancer.Translational oncology · 2024Article
- Tumour budding in head and neck cancer: what have we learnt and the next steps towards clinical implementation.British journal of cancer · 2024Article
- Prognostic Significance of Intratumoral and Peritumoral Budding in Distal Extrahepatic Bile Duct Carcinoma.Pathobiology : journal of immunopathology, molecular and cellular biology · 2024Article
- Cellular dissociation grading on biopsies of pulmonary squamous cell carcinoma provides prognostic information across all stages and is congruent with resection specimen grading.The journal of pathology. Clinical research · 2022Article
- Article
- Cellular dissociation: a missing item in the pathology report and histologic grading of oral tongue cancer?Virchows Archiv : an international journal of pathology · 2022Article
- Review
- Qualitative and Quantitative Diagnosis in Head and Neck Cancer.Diagnostics (Basel, Switzerland) · 2021Review
- Tumour budding in solid cancers.Nature reviews. Clinical oncology · 2021Review
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Authors and funding
19 authors at 5 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPre-operative treatment planning in head and neck squamous cell carcinoma (HNSCC) is mainly dictated by clinical staging, which has major shortcomings. Histologic grading is irrelevant due to its lack of prognostic impact. Recently, a novel grading termed Cellular Dissociation Grade (CDG) based on Tumour Budding and Cell Nest Size was shown to be highly prognostic for resected HNSCC. We aimed to probe the predictive and prognostic impact of CDG in the pre-operative biopsies of HNSCC.
methodsWe evaluated CDG in n = 160 pre-therapeutic biopsies from patients who received standardised treatment following German guidelines, and correlated the results with pre- and post-therapeutic staging data and clinical outcome.
resultsPre-operative CDG was highly predictive of post-operative tumour stage, including the prediction of occult lymph node metastasis. Uni- and multivariate analysis revealed CDG to be an independent prognosticator of overall, disease-specific and disease-free survival (p < 0.001). Hazard ratio for disease-specific survival was 6.1 (11.1) for nG2 (nG3) compared with nG1 tumours.
conclusionsCDG is a strong outcome predictor in the pre-treatment scenario of HNSCC and identifies patients with nodal-negative disease. CDG is a purely histology-based prognosticator in the pre-therapeutic setting that supplements clinical staging and may aide therapeutic stratification of HNSCC patients.
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