ArticleScientific reports2020
Koala retrovirus viral load and disease burden in distinct northern and southern koala populations.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Investigating the association between koala retrovirus and primary bone neoplasia in koalas (Veterinary pathology · 2026Article
- Development and Validation of a Standardised Genomic Tool for Conservation Management of the Koala (Animals : an open access journal from MDPI · 2025Article
- Infection-Induced Telomere Length Variation: Insights into Pathogenesis of Koala Retrovirus.Viruses · 2025Article
- The relationships of viral and protozoal co-infections to Chlamydia pecorum infection and chlamydiosis outcomes in northern koalas (Phascolarctos cinereus).PLoS pathogens · 2025Article
- Temporal dynamics of koala retrovirus plasma RNA load in relation to faecal glucocorticoid metabolites and Chlamydia infection.The Journal of general virology · 2025Article
- Endogenous Retroviruses in Host-Virus Coevolution: From Genomic Domestication to Functional Innovation.Genes · 2025Review
- Adaptive evolution of koala retrovirus transcription silencing and what it means for conservation.Clinical and translational medicine · 2025Article
- Article
- The Molecular Link Between TDP-43, Endogenous Retroviruses and Inflammatory Neurodegeneration in Amyotrophic Lateral Sclerosis: a Potential Target for Triumeq, an Antiretroviral Therapy.Molecular neurobiology · 2023Review
- Health Assessments of Koalas after Wildfire: A Temporal Comparison of Rehabilitated and Non-Rescued Resident Individuals.Animals : an open access journal from MDPI · 2023Article
- Genome Reference Assembly for Bottlenecked Southern Australian Koalas.Genome biology and evolution · 2023Article
- Diversity and transmission of koala retrovirus: a case study in three captive koala populations.Scientific reports · 2022Article
- Koala retrovirus load and non-A subtypes are associated with secondary disease among wild northern koalas.PLoS pathogens · 2022Article
- Koala retrovirus genetic diversity and transmission dynamics within captive koala populations.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Phylogenetic and geographical analysis of a retrovirus during the early stages of endogenous adaptation and exogenous spread in a new host.Molecular ecology · 2021Article
- Molecular Diagnosis of Koala Retrovirus (KoRV) in South Australian Koalas (Animals : an open access journal from MDPI · 2021Article
- Toll-Like Receptor and Cytokine Responses to Infection with Endogenous and Exogenous Koala Retrovirus, and Vaccination as a Control Strategy.Current issues in molecular biology · 2021Review
- Retroviral integrations contribute to elevated host cancer rates during germline invasion.Nature communications · 2021Article
- Koala retrovirus epidemiology, transmission mode, pathogenesis, and host immune response in koalas (Phascolarctos cinereus): a review.Archives of virology · 2020Review
- Koala retrovirus diversity, transmissibility, and disease associations.Retrovirology · 2020Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Koala retrovirus (KoRV) displays features of both an endogenous and exogenous virus and is linked to neoplasia and immunosuppression in koalas. This study explores the apparent differences in the nature and impact of KoRV infection between geographically and genetically separated "northern" and "southern" koala populations, by investigating the disease status, completeness of the KoRV genome and the proviral (DNA) and viral (RNA) loads of 71 northern and 97 southern koalas. All northern animals were positive for all KoRV genes (gag, pro-pol and env) in both DNA and RNA forms, whereas many southern animals were missing one or more KoRV genes. There was a significant relationship between the completeness of the KoRV genome and clinical status in this population. The proviral and viral loads of the northern population were significantly higher than those of the southern population (P < 0.0001), and many provirus-positive southern animals failed to express any detectable KoRV RNA. Across both populations there was a positive association between proviral load and neoplasia (P = 0.009). Potential reasons for the differences in the nature of KoRV infection between the two populations are discussed.
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