Evidence map›Paper›PMID 31937674›Full record

ArticlemSystems2020

Human Colon Mucosal Biofilms and Murine Host Communicate via Altered mRNA and microRNA Expression during Cancer.

Sarah Tomkovich, Raad Z Gharaibeh, Christine M Dejea, Jillian L Pope, Jinmai Jiang, Kathryn Winglee, Josee Gauthier, Rachel C Newsome, Ye Yang, Anthony A Fodor and 3 more

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 38 citations in OpenAlex.

  1. Microbiology spectrum · 2026
    Article
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  5. Review
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  12. Gut microbiota in colorectal cancer development and therapy.Nature reviews. Clinical oncology · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2022
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Sarah Tomkovich *Department of Medicine, University of Florida, Gainesville, Florida, USA.
Raad Z Gharaibeh *Department of Medicine, University of Florida, Gainesville, Florida, USA.
Christine M DejeaBloomberg-Kimmel Institute of Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.
Jillian L PopeDepartment of Medicine, University of Florida, Gainesville, Florida, USA.
Jinmai JiangDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
Kathryn WingleeDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina, USA.
Josee GauthierDepartment of Medicine, University of Florida, Gainesville, Florida, USA.
Rachel C NewsomeDepartment of Medicine, University of Florida, Gainesville, Florida, USA.
Ye YangDepartment of Medicine, University of Florida, Gainesville, Florida, USA.
Anthony A FodorDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina, USA.
Thomas D SchmittgenDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida, USA.
Cynthia L Sears *Bloomberg-Kimmel Institute of Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA csears@jhmi.edu Christian.Jobin@medicine.ufl.edu.
Christian Jobin *Department of Medicine, University of Florida, Gainesville, Florida, USA csears@jhmi.edu Christian.Jobin@medicine.ufl.edu.
University of Florida · USUniversity of North Carolina at Charlotte · USBloomberg (United States) · USJohns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Tumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI LENNON, ANNE MARIE · 1993 to 2022
$54.6M
Translational Research Enhancement CoreP30DK089502 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI ZACHOS, NICHOLAS CONSTANTINE · 2011 to 2020
$12.0M
The role of klebsiella pneumonia-derived colibactin in colitis-associated colon cancerR01DK073338 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOBIN, CHRISTIAN · 2007 to 2023
$5.4M
Biofilm Epidemiology and Mechanisms in Colon CancerR01CA196845 · NCI · JOHNS HOPKINS UNIVERSITY · PI GIARDIELLO, FRANCIS M, SEARS, CYNTHIA · 2016 to 2020
$4.3M
REGULATION OF IMMUNOSUPPRESSIVE MOLECULES IN IBDR01DK047700 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOBIN, CHRISTIAN · 1993 to 2014
$3.2M
Enterotoxigenic Bacteroides fragilis: A bacterial promoter of colon oncogenesisR01CA151393 · NCI · JOHNS HOPKINS UNIVERSITY · PI PARDOLL, DREW M., SEARS, CYNTHIA · 2010 to 2014
$2.7M
Characterization of microbial and host requirements for colonic biofilm assembly and biofilm-mediated colon tumorigenesisR00CA230192 · NCI · JOHNS HOPKINS UNIVERSITY · PI DREWES, JULIA L · 2020 to 2022
$747k
Mechanism by which H2S-producing bacteria influence development of colorectal cancerR21CA195226 · NCI · UNIVERSITY OF FLORIDA · PI JOBIN, CHRISTIAN · 2016 to 2017
$367k
Regulation of immunosuppresive molecules in IBDR56DK047700 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI JOBIN, CHRISTIAN · 2009 to 2009
$331k
Characterization of microbial and host requirements for colonic biofilm assembly and biofilm-mediated colon tumorigenesisK99CA230192 · NCI · JOHNS HOPKINS UNIVERSITY · PI DREWES, JULIA L · 2018 to 2019
$179k
NCI NIH HHS K99 CA230192NCI NIH HHS P30 CA006973NCI NIH HHS P50 CA062924NCI NIH HHS R00 CA230192NCI NIH HHS R01 CA151393NCI NIH HHS R01 CA196845NCI NIH HHS R21 CA195226NIDDK NIH HHS P30 DK089502NIDDK NIH HHS R01 DK047700NIDDK NIH HHS R01 DK073338NIDDK NIH HHS R56 DK047700
6 · The paper itself

Abstract

Disrupted interactions between host and intestinal bacteria are implicated in colorectal cancer (CRC) development. However, activities derived from these bacteria and their interplay with the host are unclear. Here, we examine this interplay by performing mouse and microbiota RNA sequencing on colon tissues and 16S and small RNA sequencing on stools from germfree (GF) and gnotobiotic

Indexed as

biofilmcolorectal cancergermfreemicrobiotamicroRNAstranscriptomics

Identifiers

PMID31937674
PMCPMC6967385
OpenAlexW2999679996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.