Evidence map›Paper›PMID 31937646›Full record

ArticlemBio2020

Quantitative Framework for Model Evaluation in Microbiology Research Using

Daniel M Cornforth, Frances L Diggle, Jeffrey A Melvin, Jennifer M Bomberger, Marvin Whiteley

Abstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed.

  1. Article
  2. The impact of modulator therapy on theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Bridging bench and bedside: translational omics ofEuropean respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  4. Sphingosine synergizes with polymyxin antibiotics againstMicrobiology (Reading, England) · 2026
    Article
  5. Article
  6. Article
  7. Evolutionary adaptations ofMicrobiology spectrum · 2026
    Article
  8. Article
  9. Review
  10. BioMed research international · 2026
    Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. mBio · 2025
    Article
  16. Article
  17. Review
  18. Microbiology spectrum · 2025
    Article
  19. Article
  20. Article

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel M CornforthSchool of Biological Sciences, Georgia Institute of Technology, Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia, USA dcornforth@gmail.com mwhiteley3@gatech.edu.
Frances L DiggleSchool of Biological Sciences, Georgia Institute of Technology, Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia, USA.
Jeffrey A MelvinDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Jennifer M BombergerDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Marvin WhiteleySchool of Biological Sciences, Georgia Institute of Technology, Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia, USA dcornforth@gmail.com mwhiteley3@gatech.edu.

Funding

Impact of Virome on Microbial Communities in the Respiratory TractR33HL137077 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOMBERGER, JENNIFER MELINDA · 2019 to 2021
$2.2M
Polymicrobial Interactions in the Respiratory TractR01HL142587 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOMBERGER, JENNIFER MELINDA · 2019 to 2022
$1.6M
Viral-bacterial co-infections in the lungR01HL123771 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOMBERGER, JENNIFER MELINDA · 2015 to 2018
$1.5M
Mechanisms of Pseudomonas aeruginosa virulence in polymicrobial wound infectionsR01GM116547 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI WHITELEY, MARVIN · 2016 to 2019
$1.2M
Bacterial regulatory evolution during adaptation to chronic infectionsR56HL142857 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI BROWN, SAMUEL PAUL · 2018 to 2018
$501k
NHLBI NIH HHS R01 HL123771NHLBI NIH HHS R01 HL142587NHLBI NIH HHS R33 HL137077NHLBI NIH HHS R56 HL142857NIGMS NIH HHS R01 GM116547
6 · The paper itself

Abstract

Laboratory models are a cornerstone of modern microbiology, but the accuracy of these models has not been systematically evaluated. As a result, researchers often choose models based on intuition or incomplete data. We propose a general quantitative framework to assess model accuracy from RNA sequencing data and use this framework to evaluate models of

Indexed as

Computational BiologyCystic FibrosisEpithelial CellsHumansIn Vitro TechniquesLungMicrobiological TechniquesModels, BiologicalPseudomonas aeruginosaRNA-SeqSputumcystic fibrosisinfectionmodelPseudomonas aeruginosatranscriptomics

Identifiers

PMID31937646
PMCPMC6960289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.