Evidence map›Paper›PMID 31937641›Full record

ArticlemBio2020

The Tip of the VgrG Spike Is Essential to Functional Type VI Secretion System Assembly in

Juvenal Lopez, Pek Man Ly, Mario F Feldman

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Drug-resistantClinical microbiology reviews · 2025
    Pooled it
  2. Article
  3. From screening to treatment:Microbiology spectrum · 2026
    Article
  4. Article
  5. Review
  6. mBio · 2025
    Article
  7. Whole-genome sequencing ofMicrobial genomics · 2025
    Article
  8. Article
  9. Virulence Factors and Pathogenicity Mechanisms ofAntibiotics (Basel, Switzerland) · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. ThebioRxiv : the preprint server for biology · 2023
    Article
  17. Article
  18. Uncovering the Secretion Systems ofAntibiotics (Basel, Switzerland) · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Juvenal LopezDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Pek Man LyDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Mario F FeldmanDepartment of Molecular Microbiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA mariofeldman@wustl.edu.
Washington University in St. Louis · US

Funding

INVESTIGATING TYPE VI SECRETION IN ACINETOBACTER BAUMANNII AND ITS INTERPLAY WITH ANTIBIOTIC RESISTAR01AI125363 · NIAID · WASHINGTON UNIVERSITY · PI FELDMAN, MARIO · 2016 to 2020
$1.9M
NIAID NIH HHS R01 AI125363
6 · The paper itself

Abstract

The type VI secretion system (T6SS) is a critical weapon in bacterial warfare between Gram-negative bacteria. Although invaluable for niche establishment, this machine represents an energetic burden to its host bacterium.

Indexed as

Acinetobacter baumanniiBacterial ProteinsDNA Transposable ElementsMutagenesisPlasmidsPoint MutationRepressor ProteinsType VI Secretion SystemsVirulenceBacterial ProteinsDNA Transposable ElementsRepressor ProteinsType VI Secretion Systemsbacterial competitioncontractile injection systemsecretion systemsT6SST6SS assemblytype VI secretion systemVgrG

Identifiers

PMID31937641
PMCPMC6960284
OpenAlexW2998953779

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.