Evidence map›Paper›PMID 31937585›Full record

Observational studyJournal of neurology, neurosurgery, and psychiatry2020

Haptoglobin genotype and outcome after aneurysmal subarachnoid haemorrhage.

Matthew J Morton, Isabel C Hostettler, Nabila Kazmi, Varinder S Alg, Stephen Bonner, Martin M Brown, Andrew Durnford, Benjamin Gaastra, Patrick Garland, Joan Grieve and 9 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of neurology, neurosurgery, and psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 1 country.

Matthew J MortonClinical Neurosciences, Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, Hampshire, UK.
Isabel C HostettlerStroke Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Nabila KazmiMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Varinder S AlgStroke Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Stephen BonnerDepartment of Anaesthesia, James Cook University Hospital, Middlesbrough, UK.
Martin M BrownStroke Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Andrew DurnfordWessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Benjamin GaastraWessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Patrick GarlandClinical Neurosciences, Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, Hampshire, UK.
Joan GrieveDepartment of Neurosurgery, The National Hospital of Neurology and Neurosurgery, London, UK.
Neil KitchenDepartment of Neurosurgery, The National Hospital of Neurology and Neurosurgery, London, UK.
Daniel WalshDepartment of Neurosurgery, King's College Hospital NHS Foundation Trust, London, UK.
Ardalan ZolnourianWessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Henry HouldenNeurogenetics Laboratory, The National Hospital of Neurology and Neurosurgery, London, UK.ORCID 0000-0002-2866-7777
Tom R GauntMRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Diederik O BultersWessex Neurological Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
David J WerringStroke Research Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Ian GaleaClinical Neurosciences, Clinical & Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, Hampshire, UK I.Galea@soton.ac.uk.ORCID 0000-0002-1268-5102
Genetics and Observational Subarachnoid Haemorrhage (GOSH) Study investigators
National Hospital for Neurology and Neurosurgery · GBUniversity Hospital Southampton NHS Foundation Trust · GBUniversity of Bristol · GBUniversity of Southampton · GBJames Cook University Hospital · GBKing's College Hospital NHS Foundation Trust · GBSouthampton General Hospital · GB

Funding

Cancer Research UK A19169Cancer Research UK C18281/A19169Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/4Medical Research Council MR/L01453X/1Wellcome Trust 102215Wellcome Trust 102215/2/13/2
6 · The paper itself

Abstract

objectiveAfter aneurysmal subarachnoid haemorrhage (aSAH), extracellular haemoglobin (Hb) in the subarachnoid space is bound by haptoglobin, neutralising Hb toxicity and helping its clearance. Two exons in the

methodsThe

resultsThe HP2 allele associated with a favourable long-term outcome after high-volume but not low-volume aSAH (multivariable logistic regression). However rs2000999 did not predict outcome. The HP2 allele associated with lower CSF haemoglobin-haptoglobin complex levels. The CSF Hb concentration after high-volume and low-volume aSAH was, respectively, higher and lower than the Hb-binding capacity of CSF haptoglobin.

conclusionThe HP2 allele carries a favourable long-term prognosis after high-volume aSAH. Haptoglobin and the Hb clearance pathway are therapeutic targets after aSAH.

Indexed as

AdolescentAdultAgedAged, 80 and overChildCohort StudiesDNA Copy Number VariationsFemaleGenotypeHaptoglobinsHumansIntracranial AneurysmMaleMiddle AgedPolymorphism, Single NucleotideRecovery of FunctionHaptoglobins

Identifiers

PMID31937585
PMCPMC7116595
OpenAlexW3000519449

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.