Trial reportTrials2020
Bayesian adaptive designs for multi-arm trials: an orthopaedic case study.
Trial report in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Fracture healing: from molecular and cellular mechanisms to therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Bayesian adaptive cluster-randomized designs with long primary endpoints for pragmatic weight loss studies implemented in rural communities.Contemporary clinical trials · 2026Article
- Bayesian adaptive designs for the optimisation of implementation strategies: a virtual re-execution of the Physically Active Children in Education (PACE) trials.Implementation science communications · 2026Article
- Review
- Bayesian Response-Adaptive Randomization for Cluster Randomized Controlled Trials.Statistics in medicine · 2026Article
- A case study in teaching and learning the design, conduction, and analysis of Bayesian adaptive trials through an application.Journal of clinical and translational science · 2026Article
- Adaptive designs for trials aiming to optimise implementation strategies and the effect of an additional interim analysis: a simulation study.BMC medical research methodology · 2025Article
- Experimental designs used for optimising the effects of health interventions and implementation strategies: a scoping review.BMC health services research · 2025Article
- Properties of adaptive, cluster-randomised controlled trials with few clusters: a simulation study.Implementation science : IS · 2025Article
- A practical guide to adopting Bayesian analyses in clinical research.Journal of clinical and translational science · 2024Article
- Conducting a bayesian multi-armed trial with response adaptive randomization for comparative effectiveness of medications for CSPN.Contemporary clinical trials communications · 2023Article
- Bayesian approach for design and analysis of medical device trials in the era of modern clinical studies.Medical review (2021) · 2023Article
- Extracorporeal cardiopulmonary resuscitation for refractory OHCA: lessons from three randomized controlled trials-the trialists' view.European heart journal. Acute cardiovascular care · 2023Article
- A Bayesian multi-arm multi-stage clinical trial design incorporating information about treatment ordering.Statistics in medicine · 2023Article
- Simulation study for evaluating an adaptive-randomisation Bayesian hybrid trial design with enrichment.Contemporary clinical trials communications · 2023Article
- Dietary Temperature's Influence on Energy Balance in Humans: Protocol for a Randomized Controlled Trial and Crossover Design.JMIR research protocols · 2023Article
- Group sequential designs in pragmatic trials: feasibility and assessment of utility using data from a number of recent surgical RCTs.BMC medical research methodology · 2022Article
- Improving clinical trials using Bayesian adaptive designs: a breast cancer example.BMC medical research methodology · 2022Article
- Personalized Risk-Based Screening Design for Comparative Two-Arm Group Sequential Clinical Trials.Journal of personalized medicine · 2022Article
- Adaptive treatment allocation and selection in multi-arm clinical trials: a Bayesian perspective.BMC medical research methodology · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBayesian adaptive designs can be more efficient than traditional methods for multi-arm randomised controlled trials. The aim of this work was to demonstrate how Bayesian adaptive designs can be constructed for multi-arm phase III clinical trials and assess potential benefits that these designs offer.
methodsWe constructed several alternative Bayesian adaptive designs for the Collaborative Ankle Support Trial (CAST), which was a randomised controlled trial that compared four treatments for severe ankle sprain. These designs incorporated response adaptive randomisation (RAR), arm dropping, and early stopping for efficacy or futility. We studied the operating characteristics of the Bayesian designs via simulation. We then virtually re-executed the trial by implementing the Bayesian adaptive designs using patient data sampled from the CAST study to demonstrate the practical applicability of the designs.
resultsWe constructed five Bayesian adaptive designs, each of which had high power and recruited fewer patients on average than the original designs target sample size. The virtual executions showed that most of the Bayesian designs would have led to trials that declared superiority of one of the interventions over the control. Bayesian adaptive designs with RAR or arm dropping were more likely to allocate patients to better performing arms at each interim analysis. Similar estimates and conclusions were obtained from the Bayesian adaptive designs as from the original trial.
conclusionsUsing CAST as an example, this case study shows how Bayesian adaptive designs can be constructed for phase III multi-arm trials using clinically relevant decision criteria. These designs demonstrated that they can potentially generate earlier results and allocate more patients to better performing arms. We recommend the wider use of Bayesian adaptive approaches in phase III clinical trials.
trial registrationCAST study registration ISRCTN, ISRCTN37807450. Retrospectively registered on 25 April 2003.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.