Evidence map›Paper›PMID 31937327›Full record

ArticleBMC biology2020

Optogenetic activation of parvalbumin and somatostatin interneurons selectively restores theta-nested gamma oscillations and oscillation-induced spike timing-dependent long-term potentiation impaired by amyloid β oligomers.

Kyerl Park, Jaedong Lee, Hyun Jae Jang, Blake A Richards, Michael M Kohl, Jeehyun Kwag

Open access · goldAbstract read
In one paragraph

Article in BMC biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 83 citations in OpenAlex.

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  5. Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Kyerl ParkDepartment of Brain and Cognitive Engineering, Korea University, Seoul, 02841, Republic of Korea.
Jaedong LeeDepartment of Brain and Cognitive Engineering, Korea University, Seoul, 02841, Republic of Korea.
Hyun Jae JangDepartment of Brain and Cognitive Engineering, Korea University, Seoul, 02841, Republic of Korea.
Blake A RichardsDepartment of Biological Sciences, University of Toronto Scarborough, Toronto, M1C 1A4, Canada.
Michael M KohlDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK.
Jeehyun KwagDepartment of Brain and Cognitive Engineering, Korea University, Seoul, 02841, Republic of Korea. jkwag@korea.ac.kr.ORCID 0000-0002-0091-6532
Korea University · KRUniversity of Oxford · GBUniversity of Toronto · CA

Funding

Medical Research Council MR/T004363/1
6 · The paper itself

Abstract

backgroundAbnormal accumulation of amyloid β

resultsTargeted whole-cell patch-clamp recordings and optogenetic manipulations of PV and SST interneurons during in vivo-like, optogenetically induced theta-nested gamma oscillations in vitro revealed that AβO

conclusionsOur results reveal that AβO

Indexed as

HippocampusAction PotentialsAmyloid beta-PeptidesAnimalsInterneuronsLong-Term PotentiationMiceOptogeneticsParvalbuminsPeptide FragmentsSomatostatinAmyloid beta-Peptidesamyloid beta-protein (1-42)ParvalbuminsPeptide FragmentsSomatostatinAlzheimer’s diseaseAmyloid beta oligomersHippocampusOptogeneticsParvalbumin interneuronSomatostatin interneuronSpike timing-dependent long-term potentiationSynapse-specific dysfunctionTheta-nested gamma oscillations

Identifiers

PMID31937327
PMCPMC6961381
OpenAlexW2998879414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.