ArticleBMC gastroenterology2020
Associations between disease activity, social support and health-related quality of life in patients with inflammatory bowel diseases: the mediating role of psychological symptoms.
Article in BMC gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Ustekinumab improves health-related quality of life in patients with moderate-to-severe Crohn's disease: Results up to Week 104 of the STARDUST trial.United European gastroenterology journal · 2023Trial
- Psychological adaptation and health-related quality of life in inflammatory bowel disease: a 5-year follow-up study.Research in psychotherapy (Milano) · 2026Article
- Optimism and mindfulness are associated with decreased abdominal pain among adolescents with inflammatory bowel disease.Journal of the Canadian Association of Gastroenterology · 2026Article
- Unmasking the Silent Struggle: The Impact of Psychological Distress and Social Support on Health-Related Quality of Life in Crohn's and Ulcerative Colitis.JMA journal · 2026Article
- Psychological distress links to magnetic resonance enterography abnormalities in Crohn's disease.Insights into imaging · 2026Article
- The Impact of Informal Caregiving on Patient-Reported Outcomes, Psychological Well-Being and Quality of Life in Inflammatory Bowel Disease: A Systematic Review.Nursing reports (Pavia, Italy) · 2026Review
- Development and validation of a model incorporating choroid plexus morphology from brain MRI to predict anti-TNF-α therapy outcomes in Crohn's disease.BMC gastroenterology · 2026Article
- Article
- Latent profiles of self-management behavior and associated factors among Chinese patients with ulcerative colitis.Frontiers in public health · 2026Article
- Association between social support and quality of life in community-dwelling schizophrenics: the mediating roles of anxiety and depression symptoms.Health and quality of life outcomes · 2025Article
- Towards an Asian paradigm of inflammatory bowel disease management: A comparative review of China and Japan.Intractable & rare diseases research · 2025Review
- The role of social support in the association between quality of life and demoralization in patients with inflammatory bowel disease: a cross-sectional study.Frontiers in psychology · 2025Article
- Mediating role of social support between stigma and social alienation in patients with inflammatory bowel disease: a cross-sectional study.Frontiers in psychology · 2025Article
- Are Depression and Anxiety Underdiagnosed in Socially Vulnerable Patients With Inflammatory Bowel Disease?Inflammatory bowel diseases · 2024Article
- Chronic illness trajectory-based nursing intervention improves the self-care abilities of patients with inflammatory bowel disease.American journal of translational research · 2024Article
- Article
- A qualitative analysis of stress experiences and coping strategies in adolescents with Crohn's disease.BMC psychiatry · 2023Article
- Translation and evaluation of the simplified Chinese version of the rating form of IBD patient concerns.BMC gastroenterology · 2022Article
- Nirvana: A Qualitative Study of Posttraumatic Growth in Adolescents and Young Adults with Inflammatory Bowel Disease.Children (Basel, Switzerland) · 2022Article
- Notable gaps between patients' and physicians' perspectives on communication and disease management in Japan: multifacetedTherapeutic advances in gastroenterology · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have indicated that disease activity, psychological symptoms and social support were associated with health-related quality of life (HRQoL) in patients with inflammatory bowel diseases(IBD). However, it is unclear how disease activity, psychological symptoms and social support interact to affect HRQoL. The main purpose of this study was to examine the mediation effect of psychological symptoms in the relationship between disease activity, social support and HRQoL.
methodsThis was a cross-sectional study, which collected data using convenience sampling, between December 2016 and March 2018, from the Third XiangyaHospital of Central South University in Changsha, China. An online self-administered questionnaire (including demographic and clinical information), Inflammatory Bowel Disease Questionnaire, Disease Activity Indices scale, Hospital Anxiety and Depression Scale and Social Support Rating Scale, were administered to each participant. Descriptive statistics and Pearson's correlations were used to summarize data, whereas PROCESS analysis was performed to examine the pre-specified mediation effect.
resultsA total of 199 patients with IBD were included. Disease activity indices (DAI) and hospital anxiety and depression (HAD) were negatively correlated with HRQoL (β = - 3.37, - 2.54 respectively, P < 0.001), while social support was positively correlated with HRQoL (β = 1.38, P < 0.01). HAD partially mediated the negative relationship between DAI and HRQoL (β = - 0.83, P < 0.001) with the mediation effect ratio of 24.6%, and completely mediated the positive relationship between social support and HRQoL (β = 1.20, P < 0.001).
conclusionsPsychological symptoms acted as a mediator in the relationship between disease activity, social support and HRQoL. Interventions to improve HRQoL in patients with IBD should take into account the mediation effect of psychological symptoms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.