Evidence map›Paper›PMID 31937249›Full record

ArticleBMC nephrology2020

Vascular access-specific health-related quality of life impacts among hemodialysis patients: qualitative development of the hemodialysis access-related quality of life (HARQ) instrument.

Robert J Nordyke, Gina Nicholson, Shawn M Gage, Ted Lithgow, Jonathan Himmelfarb, Matthew B Rivara, Ron D Hays, Karen Woo, John Devin Peipert

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05654103 (Randomized Controlled Trial Comparing endoAVF Versus surgAVF), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05654103 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Randomized Controlled Trial Comparing endoAVF Versus surgAVF

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2027Enrolled90ConditionsEnd Stage Renal Disease on DialysisArmsendoAVF, surgAVF
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Robert J NordykeBeta6 Consulting Group, Los Angeles, CA, USA. bob@beta6consulting.com.ORCID 0000-0003-2424-7852
Gina NicholsonBeta6 Consulting Group, Los Angeles, CA, USA.
Shawn M GageHumacyte Inc., Durham, NC, USA.
Ted LithgowHumacyte Inc., Durham, NC, USA.
Jonathan HimmelfarbDivision of Nephrology, Department of Medicine, University of Washington, Seattle, WA, USA.
Matthew B RivaraDivision of Nephrology, Department of Medicine, University of Washington, Seattle, WA, USA.
Ron D HaysDepartment of Medicine, UCLA, Los Angeles, CA, USA.
Karen WooDepartment of Surgery, UCLA, Los Angeles, CA, USA.
John Devin PeipertDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Humacyte (United States) · USUniversity of Washington · USBetah Associates · USNorthwestern University · US

Funding

Humacyte, Inc. n/a
6 · The paper itself

Abstract

backgroundEnd stage kidney disease and hemodialysis dependence are associated with impairments in health-related quality of life (HRQOL), which may be related to vascular access (VA). Few HRQOL measures are VA-specific and none differentiate HRQOL impact by VA type. We developed a VA-targeted HRQOL measure to distinguish the impact of fistulas, grafts and catheters.

methodsWe created an initial item pool based on literature review and then conducted focus groups at 4 US sites with 37 adults and interviews with nine dialysis clinicians about VA's impact on HRQOL. We then drafted the Hemodialysis Access-Related Quality of Life (HARQ) measure and cognitively tested it with 17 hemodialysis patients. Focus group and cognitive interview participants were diverse in age, gender, years on dialysis, and VA.

resultsWe identified six domains for the HARQ: symptoms, physical functioning, emotional impacts, social and role functioning, sleep, and care-related burdens. Cognitive interviews indicated that items were easily understood and supported content validity. Attributing HRQOL impact to VA as opposed to other hemodialysis burden was challenging for some items. Some items were dropped that were considered redundant by patients, limitations while dressing was added, and reference to VA-specific impact was included for each item. The average Flesch-Kincaid reading grade level for the revised 47-item HARQ was 5.3.

conclusionsThe HARQ features VA-specific content not addressed in other HRQOL measures, making it ideal for comparisons of different VA types and new VA technologies. The psychometric properties of the HARQ will be evaluated in future research.

Indexed as

Quality of LifeAdultAgedCatheterizationCatheterization, Central VenousCathetersFemaleFocus GroupsHumansKidney Failure, ChronicMaleMiddle AgedRenal DialysisSurveys and QuestionnairesHemodialysisQualitative developmentQuality of lifeVascular access

Identifiers

PMID31937249
PMCPMC6958666
OpenAlexW3008544433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.