Evidence map›Paper›PMID 31936750›Full record

ArticleCancers2020

Triple-Negative Primary Breast Tumors Induce Supportive Premetastatic Changes in the Extracellular Matrix and Soluble Components of the Lung Microenvironment.

Braeden Medeiros, David Goodale, Carl Postenka, Lori E Lowes, Patti Kiser, Stephen Hearn, Nikki Salmond, Karla C Williams, Alison L Allan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Premetastatic niche mechanics and organotropism in breast cancer.npj biological physics and mechanics · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Shaping Oncogenic Microenvironments: Contribution of Fibronectin.Frontiers in cell and developmental biology · 2024
    Review
  7. Article
  8. Review
  9. The Premetastatic Lymph Node Niche in Gynecologic Cancer.International journal of molecular sciences · 2023
    Article
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Braeden MedeirosDepartment of Anatomy & Cell Biology, Western University, London, ON N6A 5W9, Canada.
David GoodaleLondon Regional Cancer Program, London Health Sciences Centre, London, ON N6A 5W9, Canada.
Carl PostenkaLondon Regional Cancer Program, London Health Sciences Centre, London, ON N6A 5W9, Canada.
Lori E LowesLondon Regional Cancer Program and Flow Cytometry, London Health Sciences Centre, London, ON N6A 5W9, Canada.
Patti KiserDepartment of Pathology & Laboratory Medicine, Western University, London, ON N6A 3K7, Canada.
Stephen HearnBiotron Research Centre, Western University, London, ON N6A 3K7, Canada.
Nikki SalmondFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Karla C WilliamsFaculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Alison L AllanDepartment of Anatomy & Cell Biology, Western University, London, ON N6A 5W9, Canada.
Western University · CALondon Health Sciences Centre · CAUniversity of British Columbia · CA

Funding

Breast Cancer Society of Canada 0Canadian Cancer Society Research Institute 316332Cancer Research Society 22386London Health Sciences Foundation 0Ontario Council on Graduate Studies, Council of Ontario Universities 0
6 · The paper itself

Abstract

The lung is one of the deadliest sites of breast cancer metastasis, particularly in patients with triple-negative (TN) disease. We hypothesized that the presence of a TN primary breast tumor induces changes in the extracellular matrix (ECM) and soluble components of the lung microenvironment that support metastatic behavior. SUM159 (TN) and MCF7 (luminal A) breast cancer cells were injected into mice, and primary breast tumors were established prior to assessing metastatic niche changes. We observed increased CD117

Indexed as

breast cancerbreast cancer molecular subtypeextracellular vesicles (EVs)lung metastasisorgan tropism

Identifiers

PMID31936750
PMCPMC7016570
OpenAlexW3000294122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.