Evidence map›Paper›PMID 31936688›Full record

ArticleMolecules (Basel, Switzerland)2020

Bioaffinity Fishing Procedure Using Secretory Phospholipase A2 for Screening for Bioactive Components: Modulation of Pharmacological Effect Induced by sPLA2 from

Adeilso Bispo Dos Santos Junior, Cinthia I Tamayose, Marcelo J P Ferreira, Mariana N Belchor, Caroline R C Costa, Marcos Antonio de Oliveira, Marcos Hikari Toyama

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Adeilso Bispo Dos Santos JuniorBIOMOLPEP group, Instituto de Biociências, UNESP, Campus do Litoral Paulista, São Vicente CEP 11380-972, São Paulo 11380-972, Brazil.
Cinthia I TamayoseDepartamento de Botânica, Instituto de Biociências, Universidade de São Paulo, São Paulo CEP 05508-090, São Paulo, Brazil.
Marcelo J P FerreiraDepartamento de Botânica, Instituto de Biociências, Universidade de São Paulo, São Paulo CEP 05508-090, São Paulo, Brazil.
Mariana N BelchorBIOMOLPEP group, Instituto de Biociências, UNESP, Campus do Litoral Paulista, São Vicente CEP 11380-972, São Paulo 11380-972, Brazil.
Caroline R C CostaBIOMOLPEP group, Instituto de Biociências, UNESP, Campus do Litoral Paulista, São Vicente CEP 11380-972, São Paulo 11380-972, Brazil.
Marcos Antonio de OliveiraLABIMES, Instituto de Biociências, UNESP, Campus do Litoral Paulista, São Vicente CEP 11380-972, São Paulo, Brazil.
Marcos Hikari ToyamaBIOMOLPEP group, Instituto de Biociências, UNESP, Campus do Litoral Paulista, São Vicente CEP 11380-972, São Paulo 11380-972, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade de São Paulo · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2017/20291-0
6 · The paper itself

Abstract

Bioaffinity capturing of molecules allows the discovery of bioactive compounds and decreases the need for various stages in the natural compound isolation process. Despite the high selectivity of this technique, the screening and identification methodology depends on the presence of a protein to capture potential ligands. However, some proteins, such as snake secretory phospholipase A2 (sPLA2), have never been investigated using this approach. The purpose of this study was to evaluate the use of a new method for screening natural compounds using a bioaffinity-guided ultrafiltration method on

Indexed as

AnimalsBiological ProductsChromatography, High Pressure LiquidCrotalusEnzyme InhibitorsLigandsPhospholipases A2, SecretoryBiological ProductsEnzyme InhibitorsLigandsPhospholipases A2, Secretoryanti-inflammatorybioaffinitynatural compoundsultrafiltration

Identifiers

PMID31936688
PMCPMC7024236
OpenAlexW2998999121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.