Evidence map›Paper›PMID 31936624›Full record

ArticleJournal of clinical medicine2020

The Immunomodulary Effects of Systematic Exercise in Older Adults and People with Parkinson's Disease.

Jadwiga Szymura, Jadwiga Kubica, Magdalena Wiecek, Joanna Pera

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06977204 (Role of Physical Activity on Neuroinflammation in Parkinson's Disease), which is not on this map. Cited by 29 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06977204 recruitingnot on this mapstarted 2023, after this paper: background citation

Role of Physical Activity on Neuroinflammation in Parkinson's Disease

TypeobservationalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2023 to 2026Enrolled40ConditionsParkinson Disease, Physical Inactivity, Physical Disability
3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 8 syntheses or guidelines pooled it.

  1. Physical exercise and inflammation in Parkinson's disease: a review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Pooled it
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  9. Trial
  10. Intensive multidisciplinary rehabilitation modulates serumFrontiers in cellular neuroscience · 2026
    Article
  11. Review
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  15. Therapeutic Mechanisms of Exercise in Parkinson's Disease.International journal of molecular sciences · 2025
    Review
  16. Neuroplasticity in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jadwiga SzymuraDepartment of Clinical Rehabilitation, Faculty of Motor Rehabilitation, University of Physical Education in Krakow, 31-571 Krakow, Poland.
Jadwiga KubicaInstitute of Physiotherapy, Faculty of Health Science, Jagiellonian University Medical College, 31-126 Krakow, Poland.
Magdalena WiecekDepartment of Physiology and Biochemistry, Faculty of Physical Education and Sport, University of Physical Education in Krakow, 31-571 Krakow, Poland.
Joanna PeraDepartment of Neurology, Faculty of Medicine, Jagiellonian University Medical College, 31-503 Krakow, Poland.

Funding

Narodowe Centrum Nauki Dec. 2018/02/X/NZ7/01635
6 · The paper itself

Abstract

We sought to investigate whether regular balance training of moderate intensity (BT) has an effect on changes in selected cytokines, neurotrophic factors, CD200 and fractalkine in healthy older adults and participants with Parkinson's disease (PD). Sixty-two subjects were divided into groups depending on experimental intervention: (1) group of people with PD participating in BT (PDBT), (2) group of healthy older people participating in BT (HBT), (3,4) control groups including healthy individuals (HNT) and people with PD (PDNT). Blood samples were collected twice: before and after 12 weeks of balance exercise (PDBT, HBT), or 12 weeks apart (PDNT, HNT). The study revealed significant increase of interleukin10 (PDBT,

Indexed as

inflammationneurological disordersolder peopleregular training

Identifiers

PMID31936624
PMCPMC7019419

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.