Evidence map›Paper›PMID 31936505›Full record

ArticleMolecules (Basel, Switzerland)2020

Design, Synthesis and In Vitro Characterization of Novel Antimicrobial Agents Based on 6-Chloro-9

Alexandra T Bordei Telehoiu, Diana C Nuță, Miron T Căproiu, Florea Dumitrascu, Irina Zarafu, Petre Ioniță, Carmellina D Bădiceanu, Speranța Avram, Mariana C Chifiriuc, Coralia Bleotu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Carbazole Derivatives as Potential Antimicrobial Agents.Molecules (Basel, Switzerland) · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives.International journal of molecular sciences · 2021
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Alexandra T Bordei TelehoiuDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 TraianVuia, 020956 Bucharest, Romania.
Diana C NuțăDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 TraianVuia, 020956 Bucharest, Romania.ORCID 0000-0002-7685-3291
Miron T CăproiuCenter for Organic Chemistry "C.D. Nenitzescu", Romanian Academy, 202B Spl. Independentei, 060023 Bucharest, Romania.
Florea DumitrascuCenter for Organic Chemistry "C.D. Nenitzescu", Romanian Academy, 202B Spl. Independentei, 060023 Bucharest, Romania.
Irina ZarafuDepartment of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta, 030018 Bucharest, Romania.ORCID 0000-0002-9144-5528
Petre IonițăDepartment of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry, University of Bucharest, 4-12 Regina Elisabeta, 030018 Bucharest, Romania.ORCID 0000-0002-2216-3842
Carmellina D BădiceanuDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 TraianVuia, 020956 Bucharest, Romania.
Speranța AvramDepartment of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, 1-3 Ale. Portocalelor, 060101 Bucharest, Romania.
Mariana C ChifiriucResearch Institute of the University of Bucharest (ICUB) and Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 1-3 Ale. Portocalelor, 060101 Bucharest, Romania.
Coralia BleotuȘtefan S. Nicolau Institute of Virology, Romanian Academy, 285 Mihai Bravu Avenue, 030304 Bucharest, Romania.ORCID 0000-0002-9031-338X
Carmen LimbanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, "Carol Davila" University of Medicine and Pharmacy, 6 TraianVuia, 020956 Bucharest, Romania.ORCID 0000-0001-6212-594X
Carol Davila University of Medicine and Pharmacy · ROUniversity of Bucharest · RORomanian Academy · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this paper, we aimed to exploit and combine in the same molecule the carbazole and the 1,3,4-oxadiazole pharmacophores, to obtain novel carprofen derivatives, by using two synthesis pathways. For the first route, the following steps have been followed: (i) (

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsCandida albicansCarbazolesEscherichia coliHumansMagnetic Resonance SpectroscopyMolecular StructureOxadiazolesStructure-Activity Relationship1,3,4-oxadiazoleAnti-Bacterial AgentsAnti-Infective AgentscarbazoleCarbazolesOxadiazolesantimicrobialcarbazolecarprofencytotoxicityin silicooxadiazole

Identifiers

PMID31936505
PMCPMC7024163
OpenAlexW3000118940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.