Evidence map›Paper›PMID 31936487›Full record

ArticleNutrients2020

The Effect of Donor Human Milk Fortification on The Adhesion of Probiotics In Vitro.

Anastasia Mantziari, Satu Tölkkö, Artur C Ouwehand, Eliisa Löyttyniemi, Erika Isolauri, Seppo Salminen, Samuli Rautava

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Microbiome research reports · 2023
    Review
  2. Review
  3. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Anastasia MantziariFunctional Foods Forum, Faculty of Medicine, University of Turku, Itäinen Pitkäkatu 4A, 20520 Turku, Finland.ORCID 0000-0001-8485-2224
Satu TölkköFunctional Foods Forum, Faculty of Medicine, University of Turku, Itäinen Pitkäkatu 4A, 20520 Turku, Finland.
Artur C OuwehandDuPont Nutrition and Biosciences, Sokeritehtaantie 20, 02460 Kantvik, Finland.ORCID 0000-0001-8348-0633
Eliisa LöyttyniemiUnit of Biostatistics, Department of Clinical Medicine University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland.ORCID 0000-0002-7278-6511
Erika IsolauriDepartment of Pediatrics, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
Seppo SalminenFunctional Foods Forum, Faculty of Medicine, University of Turku, Itäinen Pitkäkatu 4A, 20520 Turku, Finland.
Samuli RautavaDepartment of Pediatrics, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20520 Turku, Finland.
University of Turku · FIDuPont (Finland) · FI

Funding

Turku University Foundation 080525
6 · The paper itself

Abstract

Preterm delivery complications are the primary cause of death among children under the age of five. Preventive strategies include the use of pasteurized donor human milk (DHM), its fortification with human milk fortifiers (protein supplements), and supplementation with probiotics. Our aim was to examine the impact of DHM and fortified DHM (FDHM) on the mucus adhesion properties of two widely used probiotics. The study covered two forms of human milk fortifier, liquid and powdered, with or without probiotics and storage at 4 °C for 24 h. To test the adhesion properties of the probiotic strains, DHM+probiotics and FDHM+probiotics were prepared and added to immobilized mucus isolated from the stool of healthy Finnish infants. The probiotic adhesion was then measured by liquid scintillation. Our results suggest that addition of liquid or powdered human milk fortifier in donor human milk had no impact on probiotic adhesion. In addition, given the increased adhesion of probiotics suspended in buffer, other matrices should be further studied. These factors need to be considered when designing future intervention strategies using probiotics in preterm infants.

Indexed as

Milk, HumanProbioticsBacterial AdhesionBifidobacteriumFecesFemaleHumansInfantInfant, NewbornLacticaseibacillus rhamnosusMilk BanksMucusBifidobacterium animalis subsp. lactis Bb12human milk fortifierinfant nutritionLactobacillus rhamnosus GGpreterm infant

Identifiers

PMID31936487
PMCPMC7019708
OpenAlexW3000628890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.