Evidence map›Paper›PMID 31936432›Full record

ArticleBiomolecules2020

Molecular Insight into Stereoselective ADME Characteristics of C20-24 Epimeric Epoxides of Protopanaxadiol by Docking Analysis.

Wenna Guo, Zhiyong Li, Meng Yuan, Geng Chen, Qiao Li, Hui Xu, Xin Yang

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Advances in Ginsenosides.Biomolecules · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wenna GuoSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264000, China.
Zhiyong LiSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264000, China.
Meng YuanSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264000, China.
Geng ChenSchool of Chemistry and Chemical Engineering, Yantai University, Yantai 264000, China.
Qiao LiSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264000, China.
Hui XuSchool of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264000, China.
Xin YangSchool of Chemistry and Chemical Engineering, Yantai University, Yantai 264000, China.
Yantai University · CN

Funding

Key Research and Development Project of Shandong Province 2018GSF119010Natural Science Foundation of Shandong Province ZR2017MH061Natural Science Foundation of Shandong Province ZR2019MB054
6 · The paper itself

Abstract

Chirality is a common phenomenon, and it is meaningful to explore interactions between stereoselective bio-macromolecules and chiral small molecules with preclinical and clinical significance. Protopanaxadiol-type ginsenosides are main effective ingredients in ginseng and are prone to biotransformation into a pair of ocotillol C20-24 epoxide epimers, namely, (20

Indexed as

ATP Binding Cassette Transporter, Subfamily B, Member 1Catalytic DomainCytochrome P-450 CYP3ADammaranesEpoxy CompoundsGlucuronidesGlucuronosyltransferaseHumansMolecular Docking SimulationOxidation-ReductionPanaxSapogeninsStereoisomerismTriterpenesATP Binding Cassette Transporter, Subfamily B, Member 1Cytochrome P-450 CYP3ADammaranesEpoxy CompoundsGlucuronidesGlucuronosyltransferaseprotopanaxadiolSapogeninsTriterpenesUDP-glucuronosyltransferase, UGT1A8homology modelingmolecular docking analysismolecular interactionocotillol type ginsenoside epimersstereoselective ADME characteristics

Identifiers

PMID31936432
PMCPMC7022797
OpenAlexW3000013676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.