Evidence map›Paper›PMID 31936430›Full record

ArticleBiomolecules2020

TLR2 and TLR4 Surface and Gene Expression in White Blood Cells after Fasting and Oral Glucose, Lipid and Protein Challenges: Influence of Obesity and Sex Hormones.

M Ángeles Martínez-García, Miriam Ojeda-Ojeda, Eulalia Rodríguez-Martín, María Insenser, Samuel Moncayo, Francisco Álvarez-Blasco, Manuel Luque-Ramírez, Héctor F Escobar-Morreale

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
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  8. Review
  9. Article
  10. Review
  11. Calorie Restriction as a New Treatment of Inflammatory Diseases.Advances in nutrition (Bethesda, Md.) · 2021
    Review
  12. Article
  13. Review
  14. Genes · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

M Ángeles Martínez-GarcíaDiabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal &Universidad de Alcalá &Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28034 Madrid, Spain.ORCID 0000-0002-8354-7284
Miriam Ojeda-OjedaDiabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal &Universidad de Alcalá &Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28034 Madrid, Spain.
Eulalia Rodríguez-MartínDepartment of Immunology, Hospital Universitario Ramón y Cajal, 28034 Madrid, Spain.
María InsenserDiabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal &Universidad de Alcalá &Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28034 Madrid, Spain.ORCID 0000-0003-3168-7856
Samuel MoncayoDiabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal &Universidad de Alcalá &Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28034 Madrid, Spain.
Francisco Álvarez-BlascoDiabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal &Universidad de Alcalá &Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28034 Madrid, Spain.
Manuel Luque-RamírezDiabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal &Universidad de Alcalá &Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28034 Madrid, Spain.ORCID 0000-0002-6002-4237
Héctor F Escobar-MorrealeDiabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal &Universidad de Alcalá &Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS) & Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 28034 Madrid, Spain.ORCID 0000-0002-6890-1644
Universidad de Alcalá · ESHospital Universitario Ramón y Cajal · ES

Funding

Instituto de Salud Carlos III PI11/00357, PI15/01686 and PIE16/00050Seventh Framework Programme FP7 Marie Curie Actions-People-2010-COFUND
6 · The paper itself

Abstract

We studied if macronutrients of the diet have different effects on leukocyte activation, and if these effects are influenced by sex hormones or obesity. We analyzed leukocyte cell surface and gene expression of toll-like receptors 2 and 4 (TLR2 and TLR4) during fasting and after macronutrient loads in women with polycystic ovary syndrome and female and male controls. Fasting TLR2 surface expression in neutrophils was higher in men than in women. Obese subjects presented higher

Indexed as

Lipid MetabolismDown-RegulationFastingFemaleGlucoseGlucose Tolerance TestGonadal Steroid HormonesHumansMaleNeutrophilsObesityPostprandial PeriodToll-Like Receptor 2Toll-Like Receptor 4Up-RegulationGlucoseGonadal Steroid HormonesTLR2 protein, humanTLR4 protein, humanToll-Like Receptor 2Toll-Like Receptor 4leukocytesmacronutrient loadsobesitypolycystic ovary syndromepostprandial responsesex hormonestoll-like receptors

Identifiers

PMID31936430
PMCPMC7023426
OpenAlexW3000304547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.