ReviewInternational journal of environmental research and public health2020
Chronic and Acute Toxicities of Aflatoxins: Mechanisms of Action.
Review in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 180 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
180 citing papers in PubMed, 3 syntheses or guidelines pooled it, 478 citations in OpenAlex.
- Incidence and mortality of acute aflatoxicosis: A systematic review.Environment international · 2025Pooled it
- Association Between Aflatoxin Exposure and Haemoglobin, Zinc, and Vitamin A, C, and E Levels/Status: A Systematic Review.Nutrients · 2025Pooled it
- Therapeutic Effect of Natural Products and Dietary Supplements on Aflatoxin-Induced Nephropathy.International journal of molecular sciences · 2024Pooled it
- Impact of chronic dietary aflatoxin B1 intake on rumen fermentation, hepatic health, oxidative stress, inflammation, and glucose-lipid metabolism in fat-tailed ewes.Veterinary and animal science · 2026Article
- Aflatoxin-associated hepatocarcinogenesis in a changing climate: the gut microbiome as a missing link in the One Health framework.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Evaluation of the Efficacy of an Aflatoxin Binder in Holstein Dairy Cows in Perú Under Field Conditions.Toxins · 2026Article
- Metal-Organic Framework-Immobilized Mycotoxin-Degrading Enzymes: Interfaces, Host Design, and Food/Feed Applications.Toxins · 2026Review
- Article
- Dietary Bentonite Supplementation Improves Growth Performance of JuvenileJournal of xenobiotics · 2026Article
- Quantifying milk yield-dependent aflatoxin B1-to-M1 transfer in dairy cows: a Bayesian consensus toxicokinetic model.Archives of toxicology · 2026Article
- Novel aflatoxin oxidase CotA alleviates aflatoxin BPoultry science · 2026Article
- The Efficacy of Ultraviolet LED Cold Light Detoxification Technology in Removing Aflatoxin BACS omega · 2026Article
- Occurrence and Co-Occurrence of Regulated and Emerging Mycotoxins in Foods Marketed to U.S. Toddlers.International journal of environmental research and public health · 2026Article
- Elucidating targets and mechanisms of dietary mycotoxin carcinogenesis via network toxicology, pan-cancer analysis, and molecular simulation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- mRNA Rather than Protein Expression of Hepatic Selenoprotein H is More Sensitive to Short-term Low Aflatoxin BBiological trace element research · 2026Article
- Effects of the Temperature andToxins · 2026Article
- Silymarin conserves the efficacy of quinolone and sulfonamide in Nile tilapia (Oreochromis niloticus) subjected to aflatoxicosis and Streptococcus agalactiae infection.Scientific reports · 2026Article
- Multi-faceted characterization of the gut microbiome and metabolome in patients with primary Sjögren syndrome.Cell reports. Medicine · 2026Article
- Nanotechnology in aflatoxin management: emerging tools for rapid detection and post-harvest control in grains.World journal of microbiology & biotechnology · 2026Review
- Kernel structure and varietal attributes determine aflatoxin production by Aspergillus flavus in maize (Zea mays L.).Mycotoxin research · 2026Article
120 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There are presently more than 18 known aflatoxins most of which have been insufficiently studied for their incidence, health-risk, and mechanisms of toxicity to allow effective intervention and control means that would significantly and sustainably reduce their incidence and adverse effects on health and economy. Among these, aflatoxin B1 (AFB1) has been by far the most studied; yet, many aspects of the range and mechanisms of the diseases it causes remain to be elucidated. Its mutagenicity, tumorigenicity, and carcinogenicity-which are the best known-still suffer from limitations regarding the relative contribution of the oxidative stress and the reactive epoxide derivative (Aflatoxin-exo 8,9-epoxide) in the induction of the diseases, as well as its metabolic and synthesis pathways. Additionally, despite the well-established additive effects for carcinogenicity between AFB1 and other risk factors, e.g., hepatitis viruses B and C, and the hepatotoxic algal microcystins, the mechanisms of this synergy remain unclear. This study reviews the most recent advances in the field of the mechanisms of toxicity of aflatoxins and the adverse health effects that they cause in humans and animals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.