Evidence map›Paper›PMID 31936284›Full record

ReviewMicroorganisms2020

The Use of Antimalarial Drugs against Viral Infection.

Sarah D'Alessandro, Diletta Scaccabarozzi, Lucia Signorini, Federica Perego, Denise P Ilboudo, Pasquale Ferrante, Serena Delbue

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
27.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04501965 phase2unknown statusnot on this map

Evaluation de l'efficacité et de la tolérance de Quinquina et d'un phytomédicament " ACAR " en Comparaison Avec l'Hydroxychloroquine Chez Des Adultes Malades de Covid-19 Sans symptômes

TypeinterventionalSponsorInstitute for Research and Development of Medicinal and Food Plants of GuineaRan2020 to 2020Enrolled231ConditionsCovid19ArmsHydroxychloroquine/Azithromycine, Quinquina-Stevia/Azythromycin, 4Plants/Azythromycin
NCT04502342 phase2unknown statusnot on this map

Évaluationefficacité et tolérance d'Une médication à Base de Cosphérunate et d'un phytomédicament Antiviral Par Voie Orale en Comparaison Avec un Traitement à Base d'Hydroxychloroquine Chez Des Adultes Malades Covid-19 Sans Complications

TypeinterventionalSponsorInstitute for Research and Development of Medicinal and Food Plants of GuineaRan2020 to 2020Enrolled30ConditionsCovid19ArmsHydroxycloroquine and Azythromycine, Cospherunate/Azythromycine, Cospherunate/Phytomedicine/Azythromycien
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it, 175 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. The Antiviral and Antimalarial Prodrug Artemisinin from theCurrent issues in molecular biology · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Applicability of Redirecting Artemisinins for New Targets.Global challenges (Hoboken, NJ) · 2023
    Review
  12. Five DifferentInternational journal of molecular sciences · 2023
    Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Molecules (Basel, Switzerland) · 2022
    Review
  18. Article
  19. Article
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Sarah D'AlessandroDepartment of Biomedical, Surgical and Dental Sciences, University of Milano, 20133 Milan, Italy.ORCID 0000-0001-9241-9762
Diletta ScaccabarozziDepartment of Pharmacological and Biomolecular Sciences, University of Milano, 20133 Milan, Italy.ORCID 0000-0001-8881-898X
Lucia SignoriniDepartment of Biomedical, Surgical and Dental Sciences, University of Milano, 20133 Milan, Italy.
Federica PeregoDepartment of Biomedical, Surgical and Dental Sciences, University of Milano, 20133 Milan, Italy.ORCID 0000-0003-1566-0231
Denise P IlboudoDépartement des Sciences de la Vie, University of Fada N'Gourma (UFDG), Fada N'Gourma BP 54, Burkina Faso.
Pasquale FerranteDepartment of Biomedical, Surgical and Dental Sciences, University of Milano, 20133 Milan, Italy.
Serena DelbueDepartment of Biomedical, Surgical and Dental Sciences, University of Milano, 20133 Milan, Italy.ORCID 0000-0002-3199-9369
University of Milan · ITBARKA Foundation · BF

Funding

Fondazione Cariplo 2017-0846
6 · The paper itself

Abstract

In recent decades, drugs used to treat malaria infection have been shown to be beneficial for many other diseases, including viral infections. In particular, they have received special attention due to the lack of effective antiviral drugs against new emerging viruses (i.e., HIV, dengue virus, chikungunya virus, Ebola virus, etc.) or against classic infections due to drug-resistant viral strains (i.e., human cytomegalovirus). Here, we reviewed the in vitro/in vivo and clinical studies conducted to evaluate the antiviral activities of four classes of antimalarial drugs: Artemisinin derivatives, aryl-aminoalcohols, aminoquinolines, and antimicrobial drugs.

Indexed as

antimalarial drugsemerging infectionsviruses

Identifiers

PMID31936284
PMCPMC7022795
OpenAlexW3000034834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.