Evidence map›Paper›PMID 31936150›Full record

ArticleViruses2020

RNase L Is Involved in Liposaccharide-Induced Lung Inflammation.

Ruhan Wei, Guanmin Chen, Naseh Algehainy, Chun Zeng, Chunfang Liu, Hongli Liu, Wendy Liu, Dennis Stacey, Aimin Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. A novel role of RNase L in the development of nonalcoholic steatohepatitis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ruhan WeiClinical Chemistry Program, Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA.
Guanmin ChenClinical Chemistry Program, Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA.
Naseh AlgehainyClinical Chemistry Program, Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA.
Chun ZengClinical Chemistry Program, Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA.
Chunfang LiuInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Hongli LiuClinical Chemistry Program, Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA.
Wendy LiuDepartment of Pathology, University Hospitals, Cleveland Medical Center, Cleveland, OH 44115, USA.
Dennis StaceyDepartment of BGES, Cleveland State University, Cleveland, OH 44115, USA.
Aimin ZhouClinical Chemistry Program, Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA.
Cleveland State University · USChinese Academy of Medical Sciences & Peking Union Medical College · CNUniversity Hospitals of Cleveland · US

Funding

RNase L contributes to lipid homeostasisR15HL145588 · NHLBI · CLEVELAND STATE UNIVERSITY · PI ZHOU, AIMIN · 2019 to 2019
$446k
NHLBI NIH HHS R15 HL145588
6 · The paper itself

Abstract

RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals that RNase L is highly expressed in the lung and other organs. However, the physiological roles of RNase L in the lung are largely unknown. In this study, we found that polysaccharide (LPS)-induced acute lung injury (ALI) was remarkably intensified in mice deficient in RNase L compared to wild type mice under the same condition. Furthermore, we found that RNase L mediated the TLR4 signaling pathway, and regulated the expression of various pro- and anti-inflammatory genes in the lung tissue and blood. Most importantly, RNase L function in macrophages during LPS stimulation may be independent of the 2-5A system. These findings demonstrate a novel role of RNase L in the immune response via an atypical molecular mechanism.

Indexed as

AnimalsEndoribonucleasesGene Knockout TechniquesImmunity, InnateLipopolysaccharidesLungMicePneumoniaSignal TransductionToll-Like Receptor 42-5A-dependent ribonucleaseEndoribonucleasesLipopolysaccharidesToll-Like Receptor 4Acute lung injuryLPSRNase LTLR4

Identifiers

PMID31936150
PMCPMC7019736
OpenAlexW3000261685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.