Evidence map›Paper›PMID 31935968›Full record

ArticleBiomolecules2020

General and Genomic DNA-Binding Specificity for the

James Shell Cox, Michael W Van Dyke

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Discovering the DNA-Binding Consensus of theInternational journal of molecular sciences · 2021
    Article
  4. Article
  5. Determination and Dissection of DNA-Binding Specificity for theInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

James Shell CoxDepartment of Chemistry and Biochemistry, Kennesaw State University, Kennesaw, GA 30144, USA.
Michael W Van DykeDepartment of Chemistry and Biochemistry, Kennesaw State University, Kennesaw, GA 30144, USA.
Kennesaw State University · US

Funding

National Science Foundation DBI 1624654National Science Foundation MCB 1714778NIH HHS 1R15GM104833-01
6 · The paper itself

Abstract

Transcription factors are proteins that recognize specific DNA sequences and affect local transcriptional processes. They are the primary means by which all organisms control specific gene expression. Understanding which DNA sequences a particular transcription factor recognizes provides important clues into the set of genes that they regulate and, through this, their potential biological functions. Insights may be gained through homology searches and genetic means. However, these approaches can be misleading, especially when comparing distantly related organisms or in cases of complicated transcriptional regulation. In this work, we used a biochemistry-based approach to determine the spectrum of DNA sequences specifically bound by the

Indexed as

Amino Acid SequenceBacterial ProteinsBase SequenceBinding SitesDNADNA-Binding ProteinsGene Expression Regulation, BacterialGenomicsPromoter Regions, GeneticRegulatory Elements, TranscriptionalRepressor ProteinsThermus thermophilusTranscription FactorsTranscription, GeneticBacterial ProteinsDNADNA-Binding ProteinsRepressor ProteinsTranscription FactorsDNA-binding specificityREPSAThermus thermophilus HB8transcriptional regulationTTHB023

Identifiers

PMID31935968
PMCPMC7022988
OpenAlexW2998097675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.