Evidence map›Paper›PMID 31935965›Full record

ReviewBiomolecules2020

Redox Signaling from Mitochondria: Signal Propagation and Its Targets.

Petr Ježek, Blanka Holendová, Lydie Plecitá-Hlavatá

Abstract readReview
In one paragraph

Review in Biomolecules, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Pitfalls of Mitochondrial Redox Signaling Research.Antioxidants (Basel, Switzerland) · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Petr JežekDepartment of Mitochondrial Physiology, No. 75, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 14220, Czech Republic.
Blanka HolendováDepartment of Mitochondrial Physiology, No. 75, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 14220, Czech Republic.
Lydie Plecitá-HlavatáDepartment of Mitochondrial Physiology, No. 75, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, Prague 14220, Czech Republic.

Funding

Grantová Agentura České Republiky 17-01813S
6 · The paper itself

Abstract

Progress in mass spectroscopy of posttranslational oxidative modifications has enabled researchers to experimentally verify the concept of redox signaling. We focus here on redox signaling originating from mitochondria under physiological situations, discussing mechanisms of transient redox burst in mitochondria, as well as the possible ways to transfer such redox signals to specific extramitochondrial targets. A role of peroxiredoxins is described which enables redox relay to other targets. Examples of mitochondrial redox signaling are discussed: initiation of hypoxia-inducible factor (HIF) responses; retrograde redox signaling to PGC1α during exercise in skeletal muscle; redox signaling in innate immune cells; redox stimulation of insulin secretion, and other physiological situations.

Indexed as

Hydrogen PeroxideHypoxiaImmunityInsulin-Secreting CellsMitochondriaMuscle, SkeletalOxidation-ReductionPeroxiredoxinsProtein Processing, Post-TranslationalReactive Oxygen SpeciesSignal TransductionSuperoxidesHydrogen PeroxidePeroxiredoxinsReactive Oxygen SpeciesSuperoxidesH2O2 diffusionHIFmitochondrial superoxide formationperoxiredoxinsredox-regulation of kinasesRedox signaling from mitochondria

Identifiers

PMID31935965
PMCPMC7023504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.