Evidence map›Paper›PMID 31935871›Full record

ArticleNanomaterials (Basel, Switzerland)2020

ToxTracker Reporter Cell Lines as a Tool for Mechanism-Based (geno)Toxicity Screening of Nanoparticles-Metals, Oxides and Quantum Dots.

Sarah McCarrick, Francesca Cappellini, Amanda Kessler, Nynke Moelijker, Remco Derr, Jonas Hedberg, Susanna Wold, Eva Blomberg, Inger Odnevall Wallinder, Giel Hendriks and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Sarah McCarrickInstitute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Francesca CappelliniInstitute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
Amanda KesslerKTH Royal Institute of Technology, Division of Surface and Corrosion Science, Department of Chemistry, 100 44 Stockholm, Sweden.
Nynke MoelijkerToxys, 2333 CG Leiden, The Netherlands.
Remco DerrToxys, 2333 CG Leiden, The Netherlands.ORCID 0000-0002-2259-858X
Jonas HedbergKTH Royal Institute of Technology, Division of Surface and Corrosion Science, Department of Chemistry, 100 44 Stockholm, Sweden.ORCID 0000-0003-2100-8864
Susanna WoldKTH Royal Institute of Technology, Division of Surface and Corrosion Science, Department of Chemistry, 100 44 Stockholm, Sweden.
Eva BlombergKTH Royal Institute of Technology, Division of Surface and Corrosion Science, Department of Chemistry, 100 44 Stockholm, Sweden.
Inger Odnevall WallinderKTH Royal Institute of Technology, Division of Surface and Corrosion Science, Department of Chemistry, 100 44 Stockholm, Sweden.ORCID 0000-0003-2206-0082
Giel HendriksToxys, 2333 CG Leiden, The Netherlands.
Hanna L KarlssonInstitute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.
KTH Royal Institute of Technology · SEKarolinska Institutet · SERISE Research Institutes of Sweden · SE

Funding

The Swedish Research Council (VR) 2014-4598The Swedish Research Council (VR) 2017-03931
6 · The paper itself

Abstract

The increased use of nanoparticles (NPs) requires efficient testing of their potential toxic effects. A promising approach is to use reporter cell lines to quickly assess the activation of cellular stress response pathways. This study aimed to use the ToxTracker reporter cell lines to investigate (geno)toxicity of various metal- or metal oxide NPs and draw general conclusions on NP-induced effects, in combination with our previous findings. The NPs tested in this study (

Indexed as

DNA damagegenotoxicityhigh throughput screeningmetal oxidesnanotoxicology

Identifiers

PMID31935871
PMCPMC7023144
OpenAlexW2997395567

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.